Lipid variability and risk of microvascular complications in patients with diabetes: a systematic review and meta-analysis.

Autor: Karimi MA; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Vaezi A; Student Research Committee, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Ansari A; Medical Student, Shantou University Medical College, Shantou, Guangdong, China., Archin I; Kazan (Volga Region) Federal University, Kazan, Russia., Dadgar K; Young Researchers Elite Club, Islamic Azad University Tehran Medical Branch, Tehran, Iran., Rasouli A; School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran., Ghannadikhosh P; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran., Alishiri G; Students Research Committee, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran., Tizro N; Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran., Gharei F; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Imanparvar S; School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran., Salehi S; Department of Medicine, Ardabil Medical Sciences Branch, Islamic Azad University, Ardabil, Iran., Mazhari SA; Student Research Committee, Azerbaijan Medical University, Baku, Azerbaijan., Etemadi MH; School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Alipour M; Medical Student, Department of Medicine, Islamic Azad University Tehran Medical Sciences, Tehran, Iran., Deravi N; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. niloofarderavi@sbmu.ac.ir., Naziri M; Students Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Jazyk: angličtina
Zdroj: BMC endocrine disorders [BMC Endocr Disord] 2024 Jan 02; Vol. 24 (1), pp. 4. Date of Electronic Publication: 2024 Jan 02.
DOI: 10.1186/s12902-023-01526-9
Abstrakt: Background and Aims: The current systematic review aimed to elucidate the effects of lipid variability on microvascular complication risk in diabetic patients. The lipid components studied were as follows: High-density lipoprotein (HDL), High-density lipoprotein (LDL), Triglyceride (TG), Total Cholesterol (TC), and Remnant Cholesterol (RC).
Method: We carried out a systematic search in multiple databases, including PubMed, Web of Science, and SCOPUS, up to October 2nd, 2023. After omitting the duplicates, we screened the title and abstract of the studies. Next, we retrieved and reviewed the full text of the remaining articles and included the ones that met our inclusion criteria in the study.
Result: In this research, we examined seven studies, comprising six cohort studies and one cross-sectional study. This research was conducted in Hong Kong, China, Japan, Taiwan, Finland, and Italy. The publication years of these articles ranged from 2012 to 2022, and the duration of each study ranged from 5 to 14.3 years. The study group consisted of patients with type 2 diabetes aged between 45 and 84 years, with a diabetes history of 7 to 12 years. These studies have demonstrated that higher levels of LDL, HDL, and TG variability can have adverse effects on microvascular complications, especially nephropathy and neuropathic complications. TG and LDL variability were associated with the development of albuminuria and GFR decline. Additionally, reducing HDL levels showed a protective effect against microalbuminuria. However, other studies did not reveal an apparent relationship between lipid variations and microvascular complications, such as retinopathy. Current research lacks geographic and demographic diversity. Increased HDL, TG, and RC variability have been associated with several microvascular difficulties. Still, the pathogenic mechanism is not entirely known, and understanding how lipid variability affects microvascular disorders may lead to novel treatments. Furthermore, the current body of this research is restricted in its coverage. This field's lack of thorough investigations required a more extensive study and comprehensive effort.
Conclusion: The relationship between lipid variation (LDL, HDL, and TG) (adverse effects) on microvascular complications, especially nephropathy and neuropathic (and maybe not retinopathy), is proven. Physicians and health policymakers should be highly vigilant to lipid variation in a general population.
(© 2023. The Author(s).)
Databáze: MEDLINE
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