Immunomodulatory effects of epiphytic Loranthus micranthus leaf extracts collected from two host plants: Psidium guajava and Parkia biglobosa.
| Autor: | Idoko ND; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Nigeria., Chukwuma IF; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Nigeria. Chukwuma.ifeoma@unn.edu.ng., Nworah FN; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Nigeria., Mba SE; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Nigeria., Joshua PE; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Nigeria., Nwodo OFC; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine Enugu State University of Science and Technology, Enugu, Nigeria., Abusudah WF; Clinical Nutrition Department, College of Applied Medical Sciences, UMM AL-QURA University, Makkah, 24381, Saudi Arabia., Almohmadi NH; Clinical Nutrition Department, College of Applied Medical Sciences, UMM AL-QURA University, Makkah, 24381, Saudi Arabia., de Waard M; Smartox Biotechnology, 6 rue des Platanes, 38120, Saint-Egrève, France.; L'institut du thorax, INSERM, CNRS, Univ nantes, F-44007, Nantes, France.; Université de Nice Sophia-Antipolis, LabEx «Ion Channels, Science & Therapeutics, F-06560, Valbonne, France. |
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| Jazyk: | angličtina |
| Zdroj: | BMC complementary medicine and therapies [BMC Complement Med Ther] 2024 Jan 02; Vol. 24 (1), pp. 7. Date of Electronic Publication: 2024 Jan 02. |
| DOI: | 10.1186/s12906-023-04282-4 |
| Abstrakt: | Background: Immunological abnormalities are implicated in the pathogenesis of many chronic diseases. Due to the drug-related adverse effects of currently available orthodox immunomodulators, natural immunomodulators are being looked upon as potential agents to replace them in therapeutic regimens. This research aimed to investigate the immunomodulatory potential of L. micranthus extracts epiphytic on Psidium guajava (LMPGE) and Parkia biglobosa (LMPBE). Methods: Phytochemical screening and acute toxicity testing were carried out to identify the phytoconstituents and safety profiles of the extracts. The extracts' innate and adaptive immunomodulatory potentials were determined in experimental animals using in vivo leucocyte mobilization, delayed-type hypersensitivity (DTH) response, hemagglutination antibody titre, and cyclophosphamide-induced myelosuppression models. Levamisole was used as the standard drug throughout the study. Results: Compared to LMPBE, LMPGE contained significantly (p < 0.05) more tannins, cyanogenic glycosides, saponins, reducing sugars, glycosides, flavonoids, and alkaloids. Furthermore, the groups treated with the extracts had a significant (p < 0.05) increase in the total number of leucocytes, neutrophils, basophils, and antibody titers relative to the untreated control. In the same way, the treatment raised TLC in cyclophosphamide-intoxicated rats, with 250 mg/kg b. w. of LMPGE and LMPBE recording 9712.50 ± 178.00 and 8000.00 ± 105.00 × 109 /L, respectively, compared to 3425.00 ± 2 5.00 × 109 /L in the untreated group. Overall, LMPGE was more effective. Conclusions: The findings from this study suggest that L. micranthus epiphytic in Psidium guajava and Parkia biglobosa has possible immune stimulating potential. (© 2023. The Author(s).) |
| Databáze: | MEDLINE |
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