Risk assessment-based verification of the CertiPUR TM limit values for toluene diamine and methylene dianiline in flexible polyurethane foam.
| Autor: | de Kort P; EUROPUR AISBL, Brussels, Belgium., Jensen E; The Dow Chemical Company, Midland, MI, USA., Spence MW; International Isocyanate Institute, Inc, Mountain Lakes, NJ, USA., Plehiers PM; International Isocyanate Institute, Inc, Mountain Lakes, NJ, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Toxicology and industrial health [Toxicol Ind Health] 2024 Mar; Vol. 40 (3), pp. 104-116. Date of Electronic Publication: 2024 Jan 02. |
| DOI: | 10.1177/07482337231224514 |
| Abstrakt: | Flexible polyurethane foams (PUF) are used in many consumer products. PUF may contain trace levels of aromatic diamine impurities that could represent a potential health risk. The risk associated with sleeping on a PUF mattress was evaluated. Toxicity benchmarks for sensitization and non-cancer endpoints were derived from the respective points-of-departure using standard assessment factors. For the cancer endpoints, toxicity benchmarks were derived from the 25th-percentile values of animal studies. Recently published emission and migration data allowed to link exposure with the CertiPUR TM voluntary quality limits of ≤5 mg.kg -1 for 2,4-toluene diamine and 4,4'-methylene dianiline in PUF. Using conservative exposure scenarios, lifetime-average daily internal doses from the combined inhalation and dermal exposures were calculated. Margins of safety for non-cancer and sensitization endpoints were >10 4 . The theoretical excess cancer risk was ≤1.5 × 10 -7 . It is concluded that sleeping on a mattress that satisfies the CertiPUR limit value does not pose undue risk to consumers. Competing Interests: Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Patrick de Kort is employed by EUROPUR. The trade association is funded by producers of flexible polyurethane foam. Mark W Spence and Patrick M Plehiers are employed by the International Isocyanate Institute, Inc. The Institute is funded by producers of TDI and MDI. Elke Jensen is employed by Dow, a producer of raw material for polyurethane. |
| Databáze: | MEDLINE |
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