Pyrethroid susceptibility reversal in Aedes aegypti: A longitudinal study in Tapachula, Mexico.

Autor: Penilla-Navarro P; Centro Regional de Investigación en Salud Pública, Instituto Nacional de Salud Pública, Tapachula, Chiapas, México., Solis-Santoyo F; Centro Regional de Investigación en Salud Pública, Instituto Nacional de Salud Pública, Tapachula, Chiapas, México., Lopez-Solis A; Centro Regional de Investigación en Salud Pública, Instituto Nacional de Salud Pública, Tapachula, Chiapas, México., Rodriguez AD; Centro Regional de Investigación en Salud Pública, Instituto Nacional de Salud Pública, Tapachula, Chiapas, México., Vera-Maloof F; Centro Regional de Investigación en Salud Pública, Instituto Nacional de Salud Pública, Tapachula, Chiapas, México., Lozano S; Centers for Disease Control and Prevention, Arboviral Diseases Branch, Fort Collins, Colorado., Contreras-Mejía E; Jurisdiccion Sanitaria VII, Tapachula Chiapas, Antiguo Hospital General de Tapachula, Tapachula, Chiapas, Mexico., Vázquez-Samayoa G; Jurisdiccion Sanitaria VII, Tapachula Chiapas, Antiguo Hospital General de Tapachula, Tapachula, Chiapas, Mexico., Torreblanca-Lopez R; Jurisdiccion Sanitaria VII, Tapachula Chiapas, Antiguo Hospital General de Tapachula, Tapachula, Chiapas, Mexico., Perera R; Center for Vector-Borne Infectious Diseases, Colorado State University, 1685 Campus Delivery, Fort Collins, Colorado., Black Iv WC; Center for Vector-Borne Infectious Diseases, Colorado State University, 1685 Campus Delivery, Fort Collins, Colorado., Saavedra-Rodriguez K; Center for Vector-Borne Infectious Diseases, Colorado State University, 1685 Campus Delivery, Fort Collins, Colorado.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Jan 02; Vol. 18 (1), pp. e0011369. Date of Electronic Publication: 2024 Jan 02 (Print Publication: 2024).
DOI: 10.1371/journal.pntd.0011369
Abstrakt: Pyrethroid resistance in Aedes aegypti has become widespread after almost two decades of frequent applications to reduce the transmission of mosquito-borne diseases. Because few insecticide classes are available for public health use, insecticide resistance management (IRM) is proposed as a strategy to retain their use. A key hypothesis of IRM assumes that negative fitness is associated with resistance, and when insecticides are removed from use, susceptibility is restored. In Tapachula, Mexico, pyrethroids (PYRs) were used exclusively by dengue control programs for 15 years, thereby contributing to selection for high PYR resistance in mosquitoes and failure in dengue control. In 2013, PYRs were replaced by organophosphates-insecticides from a class with a different mode of action. To test the hypothesis that PYR resistance is reversed in the absence of PYRs, we monitored Ae. aegypti's PYR resistance from 2016 to 2021 in Tapachula. We observed significant declining rates in the lethal concentration 50 (LC50), for permethrin and deltamethrin. For each month following the discontinuation of PYR use by vector control programs, we observed increases in the odds of mosquitoes dying by 1.5% and 8.4% for permethrin and deltamethrin, respectively. Also, knockdown-resistance mutations (kdr) in the voltage-gated sodium channel explained the variation in the permethrin LC50s, whereas variation in the deltamethrin LC50s was only explained by time. This trend was rapidly offset by application of a mixture of neonicotinoid and PYRs by vector control programs. Our results suggest that IRM strategies can be used to reverse PYR resistance in Ae. aegypti; however, long-term commitment by operational and community programs will be required for success.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.)
Databáze: MEDLINE
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