Registry-derived stage (RD-Stage) for capturing stage at diagnosis for pancreatic carcinoma in Australia.

Autor: Evans SM; Cancer Council Victoria, Melbourne, Australia.; School of Public Health and Preventive Medicine, Monash University, Clayton, Australia., Ivanova K; Cancer Council Victoria, Melbourne, Australia., Cossio D; Cancer Alliance Queensland, Woolloongabba, Australia., Pilgrim CHC; School of Public Health and Preventive Medicine, Monash University, Clayton, Australia.; Central Clinical School, Department of Surgery, The Alfred Hospital, Monash University, Clayton, Australia., Croagh D; Department of Surgery, Monash Health and Monash University, Clayton, Australia., Zalcberg J; School of Public Health and Preventive Medicine, Monash University, Clayton, Australia.; Dept. of Medical Oncology, Alfred Health and School of Public Health and Preventive Medicine, Monash University, Clayton, Australia., Giffard D; Cancer Alliance Queensland, Woolloongabba, Australia., Golobic N; Cancer Alliance Queensland, Woolloongabba, Australia., Di Muzio B; Department of Radiology, Alfred Hospital, Australia., McLean C C; Department of Anatomical Pathology, Alfred Health, Australia., McLean K; Department of Diagnostic Imaging, Princess Alexandra Hospital, Australia., Miller GC; Envoi Specialist Pathologists, Queensland Australia.; Faculty of Medicine, University of Queensland, Queensland Australia., Nicosia S; Cancer Council Victoria, Melbourne, Australia., O'Rourke N; Department of Surgery, Royal Brisbane Hospital, Herston, Australia., Parikh S; Cancer Council Victoria, Melbourne, Australia., Standish R; Dorevitch Pathology (Geelong), Australia.; School of Medicine, Deakin University, Australia., Te Marvelde L; Cancer Council Victoria, Melbourne, Australia.; School of Public Health and Preventive Medicine, Monash University, Clayton, Australia.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Jan 02; Vol. 19 (1), pp. e0294443. Date of Electronic Publication: 2024 Jan 02 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0294443
Abstrakt: Introduction: Stage of pancreatic carcinoma at diagnosis is a strong prognostic indicator of morbidity and mortality, yet is poorly notified to population-based cancer registries ("cancer registries"). Registry-derived stage (RD-Stage) provides a method for cancer registries to use available data sources to compile and record stage in a consistent way. This project describes the development and validation of rules to capture RD-Stage (pancreatic carcinoma) and applies the rules to data currently captured in each Australian cancer registry.
Materials and Methods: Rules for deriving RD-stage (pancreatic carcinoma) were developed using the American Joint Commission on Cancer (AJCC) Staging Manual 8th edition and endorsed by an Expert Working Group comprising specialists responsible for delivering care to patients diagnosed with pancreatic carcinoma, cancer registry epidemiologists and medical coders. Completeness of data fields required to calculate RD-Stage (pancreatic carcinoma) and an overall proportion of cases for whom RD stage could be assigned was assessed using data collected by each Australian cancer registry, for period 2018-2019. A validation study compared RD-Stage (pancreatic carcinoma) calculated by the Victorian Cancer Registry with clinical stage captured by the Upper Gastro-intestinal Cancer Registry (UGICR).
Results: RD-Stage (pancreatic carcinoma) could not be calculated in 4/8 (50%) of cancer registries; one did not collect the required data elements while three used a staging system not compatible with RD-Stage requirements. Of the four cancer registries able to calculate RD-Stage, baseline completeness ranged from 9% to 76%. Validation of RD-Stage (pancreatic carcinoma) with UGICR data indicated that there was insufficient data available in VCR to stage 174/457 (38%) cases and that stage was unknown in 189/457 (41%) cases in the UGICR. Yet, where it could be derived, there was very good concordance at stage level (I, II, III, IV) between the two datasets. (95.2% concordance], Kendall's coefficient = 0.92).
Conclusion: There is a lack of standardisation of data elements and data sources available to cancer registries at a national level, resulting in poor capacity to currently capture RD-Stage (pancreatic carcinoma). RD-Stage provides an excellent tool to cancer registries to capture stage when data elements required to calculate it are available to cancer registries.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Evans et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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