A landscape of mouse mitochondrial small non-coding RNAs.

Autor: Siniscalchi C; Department of Environmental, Biological, Pharmaceutical Sciences and Technologies, University of Campania 'Luigi Vanvitelli', Caserta, Italy., Di Palo A; Department of Environmental, Biological, Pharmaceutical Sciences and Technologies, University of Campania 'Luigi Vanvitelli', Caserta, Italy., Petito G; Department of Environmental, Biological, Pharmaceutical Sciences and Technologies, University of Campania 'Luigi Vanvitelli', Caserta, Italy., Senese R; Department of Environmental, Biological, Pharmaceutical Sciences and Technologies, University of Campania 'Luigi Vanvitelli', Caserta, Italy., Manfrevola F; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Leo I; Department of Environmental, Biological, Pharmaceutical Sciences and Technologies, University of Campania 'Luigi Vanvitelli', Caserta, Italy.; Genomix4Life S.r.l., Baronissi (SA), Italy., Mosca N; Department of Environmental, Biological, Pharmaceutical Sciences and Technologies, University of Campania 'Luigi Vanvitelli', Caserta, Italy., Chioccarelli T; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Porreca V; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Marchese G; Genomix4Life S.r.l., Baronissi (SA), Italy.; Genome Research Center for Health, CRGS, Baronissi, Italy., Ravo M; Genomix4Life S.r.l., Baronissi (SA), Italy.; Genome Research Center for Health, CRGS, Baronissi, Italy., Chianese R; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Cobellis G; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Lanni A; Department of Environmental, Biological, Pharmaceutical Sciences and Technologies, University of Campania 'Luigi Vanvitelli', Caserta, Italy., Russo A; Department of Environmental, Biological, Pharmaceutical Sciences and Technologies, University of Campania 'Luigi Vanvitelli', Caserta, Italy., Potenza N; Department of Environmental, Biological, Pharmaceutical Sciences and Technologies, University of Campania 'Luigi Vanvitelli', Caserta, Italy.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Jan 02; Vol. 19 (1), pp. e0293644. Date of Electronic Publication: 2024 Jan 02 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0293644
Abstrakt: Small non-coding RNAs (ncRNAs), particularly miRNAs, play key roles in a plethora of biological processes both in health and disease. Although largely operative in the cytoplasm, emerging data indicate their shuttling in different subcellular compartments. Given the central role of mitochondria in cellular homeostasis, here we systematically profiled their small ncRNAs content across mouse tissues that largely rely on mitochondria functioning. The ubiquitous presence of piRNAs in mitochondria (mitopiRNA) of somatic tissues is reported for the first time, supporting the idea of a strong and general connection between mitochondria biology and piRNA pathways. Then, we found groups of tissue-shared and tissue-specific mitochondrial miRNAs (mitomiRs), potentially related to the "basic" or "cell context dependent" biology of mitochondria. Overall, this large data platform will be useful to deepen the knowledge about small ncRNAs processing and their governed regulatory networks contributing to mitochondria functions.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Siniscalchi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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