Chemokine Receptor Profile of T Cells and Progression Rate of Geographic Atrophy Secondary to Age-related Macular Degeneration.

Autor:	Martinez Villarruel Hinnerskov J; Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Krogh Nielsen M; Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark., Kai Thomsen A; Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Steffensen MA; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Honoré B; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark., Vorum H; Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark.; Department of Ophthalmology, Aalborg University Hospital, Aalborg, Denmark., Nissen MH; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Sørensen TL; Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jazyk:	angličtina
Zdroj:	Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2024 Jan 02; Vol. 65 (1), pp. 5.
DOI:	10.1167/iovs.65.1.5
Abstrakt:	Purpose: Geographic atrophy (GA) secondary to age-related macular degeneration is a progressive retinal degenerative disease. Systemic chemokine receptors and known risk-associated single-nucleotide polymorphisms have been associated with GA pathogenesis. Because halting progression is pivotal for patients, we investigated the association of candidate chemokine receptors and progression rate (PR) of atrophic lesions in patients with GA. Methods: This prospective observational study conducted at a single center included 85 patients with GA and 45 healthy controls. Patients were followed up after 13 months on average. Serial fundus autofluorescence images were used to determine the PR of atrophic lesions. The proportion of chemokine receptors on peripheral lymphocytes were determined by flow cytometric analysis. Results: Patients with GA had a lower proportion of CCR6 on CD8+T cells compared to healthy controls. Importantly, the proportion of CCR6 on CD4+T cells was lower in patients with fast GA progression compared to patients with slow progression of disease, suggesting that dysregulation of CCR6 could be involved in progression of GA. We also found that GA patients had a markedly higher percentage of CCR5 on CD4+ and CD8+T cells compared to healthy controls. After stratification according to ARMS2 polymorphism, we found a significantly lower level of CCR5 on CD8+T cells among patients with high-risk genotypes compared with patients with the low-risk genotype. Conclusions: Our study finds that chemokine receptors are dysregulated in patients with GA and that CCR6 might be involved in GA progression, making it a potential target for intervention.
Databáze:	MEDLINE
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