Developing a Prospective Gestational Lyme Disease Study.

Autor:	McLennan G; Laboratory Corporation of America Holdings (Labcorp), Burlington, NC, USA., Dale SE; Laboratory Corporation of America Holdings (Labcorp), Burlington, NC, USA., Gillim L; Laboratory Corporation of America Holdings (Labcorp), Burlington, NC, USA., Weinblatt V; Laboratory Corporation of America Holdings (Labcorp), Burlington, NC, USA., Wallerstein R; Laboratory Corporation of America Holdings (Labcorp), Burlington, NC, USA., Naides SJ; Laboratory Corporation of America Holdings (Labcorp), Burlington, NC, USA. Naidess@labcorp.com.
Jazyk:	angličtina
Zdroj:	Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2742, pp. 259-278.
DOI:	10.1007/978-1-0716-3561-2_18
Abstrakt:	Lyme disease in pregnancy is understudied. The few available reports of Borrelia infection during pregnancy collecting clinical outcomes, with or without confirmed fetal infection both in utero and neonatal, are limited to case reports and small series. Population-based studies are not available. We propose a prospective study of Borrelia infection during pregnancy based in obstetrical practices in both endemic and nonendemic areas, with long term follow-up of pregnancy outcomes and development assessment of offspring infected or exposed to Borrelia in utero using current serological, microscopic, culture, and molecular techniques. In addition to detection of Borrelia burgdorferi sensu stricto, additional Borrelia species and other pathogens known to be transmitted by ticks will be tested. Serial biospecimens including maternal and cord blood, maternal peripheral blood mononuclear cells and urine, and, when clinically indicated, amniotic fluid, chorionic villi, intrauterine cord blood, will be collected with clinical data, imaging, and for infections treatment medications. Offspring will be followed until age 5 years with annual developmental assessments to assess pregnancy outcomes. The study will require parallel development of a biorepository with strategies for management, data security and data sharing. A public-private partnership will be required to support the study. (© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze:	MEDLINE
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