Clinical Manifestations of an Outbreak of Monkeypox Virus in Captive Chimpanzees in Cameroon, 2016.

Autor:	Brien SC; Royal (Dick) School of Veterinary Studies and the Roslin Institute, Easter Bush Campus, The University of Edinburgh, Roslin, United Kingdom.; Ape Action Africa, Mefou Park, Cameroon., LeBreton M; Mosaic, Yaoundé, Cameroon., Doty JB; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Mauldin MR; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Morgan CN; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Pieracci EG; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Ritter JM; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Matheny A; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Tafon BG; Ape Action Africa, Mefou Park, Cameroon., Tamoufe U; Metabiota, Yaoundé, Cameroon., Missoup AD; Zoology Unit, Laboratory of Biology and Physiology of Animal Organisms, Faculty of Science, University of Douala, Cameroon., Nwobegahay J; Centre for Army Health Research, Yaoundé, Cameroon., Takuo JM; Metabiota, Yaoundé, Cameroon., Nkom F; Metabiota, Yaoundé, Cameroon., Mouiche MMM; Mosaic, Yaoundé, Cameroon.; School of Veterinary Medicine and Sciences, University of Ngaounderé, Cameroon., Feussom JMK; Cameroon Epidemiological Network for Animal Diseases, Directorate of Veterinary Services, Ministry of Livestock, Fisheries and Animal Industries, Yaoundé, Cameroon., Wilkins K; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, GA, USA., Wade A; National Veterinary Laboratory, Garoua, Cameroon., McCollum AM; Division of High Consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, Atlanta, GA, USA.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2024 Mar 26; Vol. 229 (Supplement_2), pp. S275-S284.
DOI:	10.1093/infdis/jiad601
Abstrakt:	Monkeypox virus (MPXV) is a reemerging virus of global concern. An outbreak of clade I MPXV affected 20 captive chimpanzees in Cameroon in 2016. We describe the epidemiology, virology, phylogenetics, and clinical progression of this outbreak. Clinical signs included exanthema, facial swelling, perilaryngeal swelling, and eschar. Mpox can be lethal in captive chimpanzees, with death likely resulting from respiratory complications. We advise avoiding anesthesia in animals with respiratory signs to reduce the likelihood of death. This outbreak presented a risk to animal care staff. There is a need for increased awareness and a One Health approach to preparation for outbreaks in wildlife rescue centers in primate range states where MPXV occurs. Control measures should include quarantining affected animals, limiting human contacts, surveillance of humans and animals, use of personal protective equipment, and regular decontamination of enclosures. Competing Interests: Potential conflicts of interest. All authors: No reported conflicts. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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