Reassessing potential economic value and health impact of effective Shigella vaccines.

Autor: Hausdorff WP; Center for Vaccine Innovation and Access, PATH, 455 Massachusetts Avenue NW, Washington, D.C.20001, United States of America (USA)., Anderson JD 4th; West Virginia University, Morgantown, West Virginia, USA., Bourgeois AL; Center for Vaccine Innovation and Access, PATH, 455 Massachusetts Avenue NW, Washington, D.C.20001, United States of America (USA)., Clifford A; Center for Vaccine Innovation and Access, PATH, 455 Massachusetts Avenue NW, Washington, D.C.20001, United States of America (USA)., Fleming JA; PATH, Seattle, Washington, USA., Muhib F; Center for Vaccine Innovation and Access, PATH, 455 Massachusetts Avenue NW, Washington, D.C.20001, United States of America (USA)., Pecenka C; PATH, Seattle, Washington, USA., Puett C; Stony Brook University, Stony Brook, New York, USA., Riddle MS; University of Nevada, Reno, Nevada, USA., Scheele S; Center for Vaccine Innovation and Access, PATH, 455 Massachusetts Avenue NW, Washington, D.C.20001, United States of America (USA)., Bagamian KH; Bagamian Scientific Consulting LLC, Gainesville, Florida, USA.
Jazyk: angličtina
Zdroj: Bulletin of the World Health Organization [Bull World Health Organ] 2024 Jan 01; Vol. 102 (1), pp. 65-74. Date of Electronic Publication: 2023 Dec 11.
DOI: 10.2471/BLT.23.290163
Abstrakt: The gram-negative bacterium Shigella is a leading cause of diarrheal morbidity and mortality in children in low- and middle-income countries. Several promising vaccine candidates are in late stages of clinical development against this increasingly antibiotic-resistant pathogen. However, considering the increasingly crowded and costly paediatric immunization schedule, and likely advent of other important new vaccines, it is unclear whether introduction of a Shigella vaccine would represent a high priority for international agencies or health ministries in low- and middle-income countries. To determine whether there is a compelling public health value proposition for a Shigella vaccine, we used the World Health Organization's Full Value of Vaccine Assessment analytic framework and formulated five broad scientific, policy, economic and commercial-related propositions regarding the development of a Shigella vaccine. We also explored the current regulatory, clinical, policy and commercial challenges to a Shigella -containing combination vaccine development and adoption. Through a series of literature reviews, expert consultations, social science field studies and model-based analyses, we addressed each of these propositions. As described in a series of separate publications that are synthesized here, we concluded that the economic and public health value of a Shigella vaccine may be greater than previously recognized, particularly if it is found to also be effective against less severe forms of diarrheal disease and childhood stunting. The decision by pharmaceutical companies to develop a standalone vaccine or a multipathogen combination will be a key factor in determining its relative prioritization by various stakeholders in low- and middle-income countries.
((c) 2024 The authors; licensee World Health Organization.)
Databáze: MEDLINE
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