Insufficient Bone Mineralization to Sustain Mechanical Load of Weight in Obese Boys: A Cross-Sectional Study.

Autor:	Emeriau F; Department of Pediatric Endocrinology, University Hospital, 49000 Angers, France., Amsellem-Jager J; Department of Pediatric Endocrinology, University Hospital, 49000 Angers, France.; Reference Center for Rare Pituitary Diseases, University Hospital, 49000 Angers, France.; Specialized Center for Obesity, University Hospital, 49000 Angers, France., Bouhours-Nouet N; Department of Pediatric Endocrinology, University Hospital, 49000 Angers, France.; Reference Center for Rare Pituitary Diseases, University Hospital, 49000 Angers, France.; Specialized Center for Obesity, University Hospital, 49000 Angers, France., Donzeau A; Department of Pediatric Endocrinology, University Hospital, 49000 Angers, France., Rouleau S; Department of Pediatric Endocrinology, University Hospital, 49000 Angers, France., Rerat S; Department of Pediatric Endocrinology, University Hospital, 49000 Angers, France., Labarre E; Department of Pediatric Endocrinology, University Hospital, 49000 Angers, France., Levaillant L; Department of Pediatric Endocrinology, University Hospital, 49000 Angers, France., Coutant R; Department of Pediatric Endocrinology, University Hospital, 49000 Angers, France.; Reference Center for Rare Pituitary Diseases, University Hospital, 49000 Angers, France.; Specialized Center for Obesity, University Hospital, 49000 Angers, France.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 May 17; Vol. 109 (6), pp. 1443-1453.
DOI:	10.1210/clinem/dgad760
Abstrakt:	Context: The increase in bone mineral content (BMC) and density (BMD) measured by dual-energy x-ray absorptiometry (DXA) in obese children may not sustain the mechanical load associated with weight, and the factors influencing bone mineralization are not well known. Objective: We described bone mineralization in boys with overweight/obesity and leanness in relation to body composition. Methods: Cross-sectional study in the Pediatric Endocrinology Unit of Angers University Hospital with 249 overweight/obese boys aged 8-18 who underwent DXA and insulin, testosterone, and IGF-1 measurements. Bone mineralization was compared with data from 301 lean boys of similar age and height from NHANES 2011-2015, using the same DXA model. Path analyses were performed to evaluate factors associated with total body less head (TBLH) BMC. Results: The mean age- and height-adjusted difference in TBLH BMC between obese and lean boys was 241 ± 20 g/cm2. Each 1 kg/m2 increase in BMI was associated with +39 ± 6 g of TBLH BMC in lean subjects vs + 25 ± 3 g in obese subjects (P < .05). Each 1 kg/m2 increase in lean BMI (LBMI) was associated with +78 ± 5 g of TBLH BMC in lean and obese boys, and each 1 kg/m2 increase in fat mass index (FMI) was associated with a decrease of 9 ± 3 g of TBLH BMC. The TBLH BMC was directly positively influenced by LBMI and indirectly and positively influenced by IGF-1, testosterone, and insulin (mediated through height and LBMI). FMI indirectly influenced TBLH BMC, both positively through LBMI and negatively through its negative impact on IGF-1 and testosterone. Conclusion: The increase in bone mineralization in obese children does not adapt to the increase in body mass. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society.)
Databáze:	MEDLINE
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