Mahamanalactone A, a new triterpenoid from Dysoxylum malabaricum bark: a case study for rapid identification of new metabolites via LC-HRMS profiling and database mining strategy.

Autor: Bhardwaj N; Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, India., S S; Department of Biological Sciences, National Institute of Pharmaceutical Education and Research, Hyderabad, India., Tripathi N; Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, India., Kumar S; Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, India., Lal UR; Department of Natural Products, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Mohali, India., G R; S.M. Sehgal Foundation Center for Biodiversity and Conservation, Ashoka Trust for Research in Ecology and the Environment, Bangalore, India., Guru SK; Department of Biological Sciences, National Institute of Pharmaceutical Education and Research, Hyderabad, India., Jain SK; Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, India.
Jazyk: angličtina
Zdroj: Natural product research [Nat Prod Res] 2024 Jan 01, pp. 1-6. Date of Electronic Publication: 2024 Jan 01.
DOI: 10.1080/14786419.2023.2298721
Abstrakt: In this recent investigation, the focus centred on exploring the potential phytoconstituents within the bark of Dysoxylum malabaricum . A profiling strategy employing LC-HRMS (Liquid Chromatography-High Resolution Mass Spectrometry) was implemented for the rapid identification of compounds from the bark extract. The crude extract underwent fractionation, resulting in the isolation of four previously known compounds ( 1-4 ) and a novel cycloartane triterpenoid named Mahamanalactone A ( 5 ). Compound 5 represents a cycloartane triterpenoid with a modified ring-A, featuring £-caprolactone fusion at positions 4 and 5, distinguishing it from other reported compounds where £-caprolactone is typically fused at positions 3 and 4. Cytotoxicity assessment revealed that the newly identified compound 5 exhibited a moderate cytotoxic profile (IC 50 29 to 78 µM) against a panel of cancer cell lines.
Databáze: MEDLINE
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