Histoarchitecture of stromal collagen fibers in gastrointestinal hollow organs of mice after a 30-day space flight.

Autor:	Shishkina V; Research Institute of Experimental Biology and Medicine, Burdenko Voronezh State Medical University, 394036 Voronezh, Russia., Kostin A; RUDN University, 6 Miklukho-Maklaya St, Moscow, 117198, Russia., Alexeeva N; Research Institute of Experimental Biology and Medicine, Burdenko Voronezh State Medical University, 394036 Voronezh, Russia., Klochkova S; RUDN University, 6 Miklukho-Maklaya St, Moscow, 117198, Russia., Nikityuk D; Federal State Budgetary Institution 'Federal Research Center for Nutrition, Biotechnology and Food Safety', 109240 Moscow, Russia., Volodkin A; RUDN University, 6 Miklukho-Maklaya St, Moscow, 117198, Russia., Buchwalow I; RUDN University, 6 Miklukho-Maklaya St, Moscow, 117198, Russia.; Institute for Hematopathology, 22547 Hamburg, Germany., Tiemann M; Institute for Hematopathology, 22547 Hamburg, Germany., Atiakshin D; Research Institute of Experimental Biology and Medicine, Burdenko Voronezh State Medical University, 394036 Voronezh, Russia.; RUDN University, 6 Miklukho-Maklaya St, Moscow, 117198, Russia.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2023 Dec 05; Vol. 10 (1), pp. e23287. Date of Electronic Publication: 2023 Dec 05 (Print Publication: 2024).
DOI:	10.1016/j.heliyon.2023.e23287
Abstrakt:	The digestive organs are highly sensitive to the influence of orbital flight factors and can limit the professional activities of crew members aboard the International Space Station. Connective tissue, as a system-forming matrix of the integrative-buffer metabolic environment, is of particular relevance in space biomedicine, ensuring the functioning of internal organs under an altered gravitational stimulus. However, the adaptive mechanisms of the fibrous extracellular matrix of the gastric and intestinal connective tissue have not been fully investigated under prolonged microgravity weightlessness. Using histochemical techniques, we experimentally studied the state of collagen fibers in the specific tissue microenvironment of the gastric and intestinal membranes in C57BL/6 N mice after a 30-day space flight, subsequent 7-day ground readaptation, and in animals of the relevant control groups. The 30-day stay of laboratory animals aboard the Bion-M 1 biosatellite resulted in a reduction in the fibrous extracellular matrix of connective tissue in the studied digestive organs, excepting the gastric lamina propria. Increased fibrillogenesis was revealed in the gastrointestinal mucous membranes of animals 7 days after biosatellite landing compared with the parameters of animals in the space flight group. During the experiment with ground simulated orbital flight conditions, changes in collagen fibers were not significant compared to the vivarium control group. Thus, the results obtained evidence gravisensitivity of the fibrous extracellular matrix of the intraorgan connective tissue. This fact also highlights the necessity to further improve gastrointestinal tract-related preventive measures for astronauts during orbital flight. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors. Published by Elsevier Ltd.)
Databáze:	MEDLINE
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