Adolescent alcohol disrupts development of noradrenergic neurons in the nucleus of the tractus solitarius and enhances stress behaviors in adulthood in mice in a sex specific manner.

Autor:	Aguilar LA; Department of Neural and Behavioral Sciences, Penn State College of Medicine, USA.; Currently at Department of Biology, Indiana University Bloomington, USA., Coker CR; Department of Neural and Behavioral Sciences, Penn State College of Medicine, USA.; Penn State College of Medicine, Graduate Program in Anatomy, USA.; Currently at Georgetown University School of Medicine, USA., McCullers Z; Department of Neural and Behavioral Sciences, Penn State College of Medicine, USA.; Penn State College of Medicine, Graduate Program in Biomedical Sciences, USA., Evans A; Department of Neural and Behavioral Sciences, Penn State College of Medicine, USA.; Penn State College of Medicine, Graduate Program in Biomedical Sciences, USA., Showemimo O; Department of Neural and Behavioral Sciences, Penn State College of Medicine, USA.; Penn State College of Medicine, Graduate Program in Anatomy, USA., Melkumyan M; Department of Neural and Behavioral Sciences, Penn State College of Medicine, USA.; Penn State College of Medicine, Graduate Program in Neuroscience, USA., Keller BN; Department of Neural and Behavioral Sciences, Penn State College of Medicine, USA.; Penn State College of Medicine, Graduate Program in Neuroscience, USA., Snyder AE; Department of Neural and Behavioral Sciences, Penn State College of Medicine, USA.; Penn State College of Medicine, Graduate Program in Neuroscience, USA., Bingaman SS; Department of Neural and Behavioral Sciences, Penn State College of Medicine, USA., Randall PA; Department of Anesthesiology, Penn State College of Medicine, USA., Hajnal A; Department of Neural and Behavioral Sciences, Penn State College of Medicine, USA., Browning KN; Department of Neural and Behavioral Sciences, Penn State College of Medicine, USA., Arnold AC; Department of Neural and Behavioral Sciences, Penn State College of Medicine, USA., Silberman Y; Department of Neural and Behavioral Sciences, Penn State College of Medicine, USA.
Jazyk:	angličtina
Zdroj:	Addiction neuroscience [Addict Neurosci] 2023 Dec 15; Vol. 9. Date of Electronic Publication: 2023 Oct 11.
DOI:	10.1016/j.addicn.2023.100132
Abstrakt:	Alcohol use disorders (AUDs) are common mental health issues worldwide and can lead to other chronic diseases. Stress is a major factor in the development and continuation of AUDs, and adolescent alcohol exposure can lead to enhanced stress-responsivity and increased risk for AUD development in adulthood. The exact mechanisms behind the interaction between adolescence, stress, and alcohol are not fully understood and require further research. In this regard, the nucleus of the tractus solitarius (NTS) provides dense norepinephrine projections to the extended amygdala, providing a key pathway for stress-related alcohol behaviors. While NTS norepinephrine neurons are known to be alcohol sensitive, whether adolescent alcohol disrupts NTS-norepinephrine neuron development and if this is related to altered stress-sensitivity and alcohol preference in adulthood has not previously been examined. Here, we exposed male and female C57Bl/6J mice to the commonly used adolescent intermittent ethanol (AIE) vapor model during postnatal day 28-42 and examined AIE effects on: 1) tyrosine hydroxylase (TH) mRNA expression in the NTS across various ages (postnatal day 21-90), 2) behavioral responses to acute stress in the light/dark box test in adulthood, 3) NTS TH neuron responses to acute stress and ethanol challenges in adulthood, and 4) ethanol conditioned place preference behavior in adulthood. Overall the findings indicate that AIE alters NTS TH mRNA expression and increases anxiety-like behaviors following acute stress exposure in a sex-dependent manner. These mRNA expression and behavioral changes occur in the absence of AIE-induced changes in NTS TH neuron sensitivity to either acute stress or acute alcohol exposure or changes to ethanol conditioned place preference. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Databáze:	MEDLINE
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