Neurophysiological hallmarks of Huntington's disease progression: an EEG and fMRI connectivity study.

Autor:	Ponomareva NV; Research Center of Neurology, Moscow, Russia.; Center for Genetics and Life Science, Sirius University of Science and Technology, Sochi, Russia., Klyushnikov SA; Research Center of Neurology, Moscow, Russia., Abramycheva N; Research Center of Neurology, Moscow, Russia., Konovalov RN; Research Center of Neurology, Moscow, Russia., Krotenkova M; Research Center of Neurology, Moscow, Russia., Kolesnikova E; Research Center of Neurology, Moscow, Russia., Malina D; Research Center of Neurology, Moscow, Russia., Urazgildeeva G; Research Center of Neurology, Moscow, Russia., Kanavets E; Research Center of Neurology, Moscow, Russia., Mitrofanov A; Research Center of Mental Health, Moscow, Russia., Fokin V; Research Center of Neurology, Moscow, Russia., Rogaev E; Center for Genetics and Life Science, Sirius University of Science and Technology, Sochi, Russia.; Department of Psychiatry, Umass Chan Medical School, Shrewsbury, MA, United States., Illarioshkin SN; Research Center of Neurology, Moscow, Russia.
Jazyk:	angličtina
Zdroj:	Frontiers in aging neuroscience [Front Aging Neurosci] 2023 Dec 15; Vol. 15, pp. 1270226. Date of Electronic Publication: 2023 Dec 15 (Print Publication: 2023).
DOI:	10.3389/fnagi.2023.1270226
Abstrakt:	Electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) can provide corroborative data on neurophysiological alterations in Huntington's disease (HD). However, the alterations in EEG and fMRI resting-state functional connectivity (rsFC), as well as their interrelations, at different stages of HD remain insufficiently investigated. This study aimed to identify neurophysiological alterations in individuals with preclinical HD (preHD) and early manifest HD (EMHD) by analyzing EEG and fMRI rsFC and examining their interrelationships. We found significant differences in EEG power between preHD individuals and healthy controls (HC), with a decrease in power in a specific frequency range at the theta-alpha border and slow alpha activity. In EMHD patients, in addition to the decrease in power in the 7-9 Hz range, a reduction in power within the classic alpha band compared to HC was observed. The fMRI analysis revealed disrupted functional connectivity in various brain networks, particularly within frontal lobe, putamen-cortical, and cortico-cerebellar networks, in individuals with the HD mutation compared to HC. The analysis of the relationship between EEG and fMRI rsFC revealed an association between decreased alpha power, observed in individuals with EMHD, and increased connectivity in large-scale brain networks. These networks include putamen-cortical, DMN-related and cortico-hippocampal circuits. Overall, the findings suggest that EEG and fMRI provide valuable information for monitoring pathological processes during the development of HD. A decrease in inhibitory control within the putamen-cortical, DMN-related and cortico-hippocampal circuits, accompanied by a reduction in alpha and theta-alpha border oscillatory activity, could potentially contribute to cognitive decline in HD. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Ponomareva, Klyushnikov, Abramycheva, Konovalov, Krotenkova, Kolesnikova, Malina, Urazgildeeva, Kanavets, Mitrofanov, Fokin, Rogaev and Illarioshkin.)
Databáze:	MEDLINE
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