The association between parental SARS-CoV-2 infection in pregnancy and fetal growth restriction.

Autor:	Mitta M; Department of Obstetrics and Gynecology, Emory University School of Medicine, Atlanta, GA, USA., Holt L; Department of Obstetrics and Gynecology, Emory University School of Medicine, Atlanta, GA, USA., Chandrasekaran S; Department of Obstetrics and Gynecology, Emory University School of Medicine, Atlanta, GA, USA., Dude C; Department of Obstetrics and Gynecology, Emory University School of Medicine, Atlanta, GA, USA.
Jazyk:	angličtina
Zdroj:	Journal of perinatal medicine [J Perinat Med] 2024 Jan 01; Vol. 52 (3), pp. 317-321. Date of Electronic Publication: 2024 Jan 01 (Print Publication: 2024).
DOI:	10.1515/jpm-2023-0406
Abstrakt:	Objectives: Although the relationship between maternal viral infections and fetal growth restriction (FGR) is well established, the association between SARS-CoV-2 infection in pregnancy and FGR remains unclear. We investigated the association between SARS-CoV-2 infection in pregnancy and FGR at a single county hospital. Methods: We performed a prospective cohort study with cohorts matched by gestational age and month of SARS-CoV-2 PCR testing between April 2020 and July 2022. Individuals were included if they had a SARS-CoV-2 PCR testing up to 32 weeks of gestation and had a third trimester ultrasound. Primary outcome was a diagnosis of FGR, while secondary outcomes were rates of preeclampsia, small for gestational age (SGA) and birthweight. Univariate analyses, chi-square test and logistic regression were used for analysis. Results: Our cohorts constituted of 102 pregnant individuals with a positive SARS-CoV-2 PCR test result and 103 pregnant individuals with a negative SARS-CoV-2 PCR test result in pregnancy. FGR rates were 17.8 % and 19.42 % among positive and negative SARS-CoV-2 cohorts respectively. While a statistical difference in preeclampsia rates was noted (34.31 % vs. 21.36 %, p=0.038) between cohorts, odds of getting preeclampsia based on SARS-CoV-2 test result was not significant (aOR 1.01, CI=0.97-1.01, p=0.75). No statistical difference was noted in demographics, FGR and SGA rates, and birthweight. Conclusions: Our findings suggest no association between SARS-CoV-2 infection in pregnancy and FGR at a single institution. Our results validate emerging data that additional fetal growth ultrasonographic assessment is not indicated solely based on SARS-CoV-2 infection status. (© 2023 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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