Early exposure to mercury and cardiovascular function of seven-year old children in Guadeloupe (French West Indies).
Autor: | Costet N; Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail) -UMR_S 1085, Rennes, France. Electronic address: nathalie.costet@univ-rennes.fr., Doyen M; Univ Rennes, Inserm, LTSI - UMR 1099, Rennes, France; IADI, U1254, Inserm and Université de Lorraine, Nancy, France. Electronic address: doyen.matthieu@gmail.com., Rouget F; Univ Rennes, CHU de Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, Rennes, France. Electronic address: florence.rouget@inserm.fr., Michineau L; Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail) -UMR_S 1085, Pointe à Pitre, France. Electronic address: leah.michineau@inserm.fr., Monfort C; Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail) -UMR_S 1085, Rennes, France. Electronic address: christine.monfort@inserm.fr., Cirtiu CM; Centre de Toxicologie Du Québec, Institut National de Santé Publique Du Québec, Québec, Québec, Canada. Electronic address: ciprian-mihai.cirtiu@inspq.qc.ca., Kadhel P; CHU de Guadeloupe, Univ Antilles, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, Pointe à Pitre, France. Electronic address: philippe.kadhel@gmail.com., Multigner L; Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail) -UMR_S 1085, Rennes, France. Electronic address: luc.multigner@inserm.fr., Pladys P; Univ Rennes, CHU de Rennes, Inserm, LTSI - UMR 1099, Rennes, France. Electronic address: patrick.pladys@univ-rennes.fr., Cordier S; Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail) -UMR_S 1085, Rennes, France. Electronic address: sylvaine.cordier@inserm.fr. |
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Jazyk: | angličtina |
Zdroj: | Environmental research [Environ Res] 2024 Apr 01; Vol. 246, pp. 117955. Date of Electronic Publication: 2023 Dec 29. |
DOI: | 10.1016/j.envres.2023.117955 |
Abstrakt: | Background: The cardiotoxicity of prenatal exposure to mercury has been suggested in populations having regular contaminated seafood intake, though replications in the literature are inconsistent. Methods: The Timoun Mother-Child Cohort Study was set up in Guadeloupe, an island in the Caribbean Sea where seafood consumption is regular. At seven years of age, 592 children underwent a medical examination, including cardiac function assessment. Blood pressure (BP) was taken using an automated blood pressure monitor, heart rate variability (HRV, 9 parameters) and electrocardiogram (ECG) characteristics (QT, T-wave parameters) were measured using Holter cardiac monitoring during the examination. Total mercury concentrations were measured in cord blood at birth (median = 6.6 μg/L, N = 399) and in the children's blood at age 7 (median = 1.7 μg/L, N = 310). Adjusted linear and non-linear modelling was used to study the association of each cardiac parameter with prenatal and childhood exposures. Sensitivity analyses included co-exposures to lead and cadmium, adjustment for maternal seafood consumption, selenium and polyunsaturated fatty acids (n3-PUFAs), and for sporting activity. Results: Higher prenatal mercury was associated with higher systolic BP at 7 years of age (β Conclusion: Our study suggests sex-specific and non-monotonic modifications in some cardiac health parameters following prenatal exposure to mercury in pre-pubertal children from an insular fish-consuming population. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023. Published by Elsevier Inc.) |
Databáze: | MEDLINE |
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