The impact of early tracheostomy on neurodevelopmental outcomes of infants with severe bronchopulmonary dysplasia exposed to postnatal corticosteroids.

Autor: Taha A; Division of Neonatology, Children's Mercy Kansas City, Kansas City, MO, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA., Akangire G; Division of Neonatology, Children's Mercy Kansas City, Kansas City, MO, USA. gakangire@cmh.edu.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA. gakangire@cmh.edu., Noel-Macdonnell J; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.; Department of Health Services and Outcomes Research, Children's Mercy Kansas City, Kansas City, MO, USA., Gladdis T; Division of Neonatology, Children's Mercy Kansas City, Kansas City, MO, USA.; Department of Developmental and Behavioral Health, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA., Manimtim W; Division of Neonatology, Children's Mercy Kansas City, Kansas City, MO, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2024 Jul; Vol. 44 (7), pp. 979-987. Date of Electronic Publication: 2023 Dec 29.
DOI: 10.1038/s41372-023-01864-5
Abstrakt: Objective: To compare the cognitive, language and motor scores of infants with severe BPD exposed to postnatal corticosteroids (PCS) and had early (ET), late (LT) or no tracheostomy (NT).
Methods: Retrospective study was designed to compare the developmental outcomes of 71 infants born between 2010 and 2017 with severe BPD exposed to PCS and had ET (≤122 days), LT (>122 days), or NT.
Results: Cognitive scores were lower in LT versus NT and ET (p = 0.050); motor scores were worse in LT versus NT and ET (p = 0.004). Dexamethasone use was higher in LT versus NT and ET (p = 0.040). Adjusted for PCS, odds for major cognitive impairment were 90% less in ET versus LT. Trend for improved language and motor outcomes was seen in ET versus LT.
Conclusion: Infants with severe BPD exposed to PCS and had ET had significantly better cognitive, and trend toward improved language and motor outcomes.
(© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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