Decreased oxytocin plasma levels and oxytocin receptor expression associated with aggressive behavior in aggressive-impulsive disorders.

Autor: Diaz-Marsá M; Biomedical Research Networking Consortium for Mental Health (CIBERSAM), Spain; Department of Psychiatry and Medical Psychology, Faculty of Medicine, UCM, Spain., López-Villatoro JM; Institute of Health Research, Hospital Clínico San Carlos (IdISSC), Spain; Department of Psychiatry and Medical Psychology, Faculty of Medicine, UCM, Spain. Electronic address: jolope09@ucm.es., De la Torre-Luque A; Biomedical Research Networking Consortium for Mental Health (CIBERSAM), Spain; Department of Psychiatry and Medical Psychology, Faculty of Medicine, UCM, Spain., MacDowell KS; Department of Pharmacology and Toxicology, Faculty of Medicine, University Complutense de Madrid (UCM), Institute of Health Research Hospital 12 de Octubre (imas12), University Institute of Research in Neurochemistry UCM, Spain; Biomedical Research Networking Consortium for Mental Health (CIBERSAM), Spain., Galvez-Merlin A; Department of Psychiatry and Medical Psychology, Faculty of Medicine, UCM, Spain., Gómez Del Barrio A; Biomedical Research Networking Consortium for Mental Health (CIBERSAM), Spain; Marqués de Valdecilla University Hospital, Eating Disorders Unit, Department of Psychiatry, Santander, Spain; Valdecilla Biomedical Research Institute (IDIVAL), Santander, Spain., Ruiz-Guerrero F; Marqués de Valdecilla University Hospital, Eating Disorders Unit, Department of Psychiatry, Santander, Spain; Valdecilla Biomedical Research Institute (IDIVAL), Santander, Spain., Beato-Fernández L; General Hospital of Ciudad Real. Ciudad Real, Spain., Polo-Montes F; General Hospital of Ciudad Real. Ciudad Real, Spain., León-Velasco M; General Hospital of Ciudad Real. Ciudad Real, Spain., Martín-Hernández D; Department of Pharmacology and Toxicology, Faculty of Medicine, University Complutense de Madrid (UCM), Institute of Health Research Hospital 12 de Octubre (imas12), University Institute of Research in Neurochemistry UCM, Spain; Biomedical Research Networking Consortium for Mental Health (CIBERSAM), Spain., Carrasco-Diaz A; Francisco de Vitoria University, Madrid, Spain., Leza JC; Department of Pharmacology and Toxicology, Faculty of Medicine, University Complutense de Madrid (UCM), Institute of Health Research Hospital 12 de Octubre (imas12), University Institute of Research in Neurochemistry UCM, Spain; Biomedical Research Networking Consortium for Mental Health (CIBERSAM), Spain., Carrasco JL; Biomedical Research Networking Consortium for Mental Health (CIBERSAM), Spain; Department of Psychiatry and Medical Psychology, Faculty of Medicine, UCM, Spain.
Jazyk: angličtina
Zdroj: Journal of psychiatric research [J Psychiatr Res] 2024 Feb; Vol. 170, pp. 200-206. Date of Electronic Publication: 2023 Dec 23.
DOI: 10.1016/j.jpsychires.2023.12.032
Abstrakt: Introduction: This study aims to enhance the understanding of the association between the phenotypic and endophenotypic characteristics of impulsive-aggressive disorders, through the study of plasma oxytocin (OXT) and oxytocin receptor (OXTR) levels in patients with borderline personality disorder (BPD) and patients with eating disorders (ED), as well as to examine the relationship of OXT system with aggressive behavior in these disorders.
Methods: 68 patients with BPD, 67 patients with ED and 57 healthy control subjects were examined for plasma oxytocin levels and protein expression of OXTR in blood mononuclear cells. Aggressive behavior was assessed using the State-Trait Anger Expression Inventory (STAXI-2). Other self and hetero-aggressive behaviors were also evaluated through interviews.
Results: BPD and ED patients exhibited significantly lower plasma oxytocin levels than control subjects. Furthermore, BPD patients demonstrated significantly reduced expression of OXTR compared to controls. Plasma oxytocin levels negatively correlated with verbal aggression, while OXTR expression was inversely associated with the STAXI trait subscale.
Conclusions: The findings validate the existence of oxytocin system dysfunction in impulsive-aggressive disorders. They also support the link between low OXT levels in plasma and OXTR expression and the impulsive-aggressive behavior that characterizes these patients in both state and trait situations.
Competing Interests: Declaration of competing interest This work was supported by the PI20/01471 and PI16/01949 projects, integrated in the Plan National de I + D + I, AES 20–23 and 16–19 respectively; funded by the ISCIII and co-funded by the European Regional Development Fund (ERDF). “A way to make Europe”.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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