Evaluating the risk of phthalate and non-phthalate plasticizers in dust samples from 100 Japanese houses.

Autor: Shinohara N; Research Institute of Science for Safety and Sustainability (RISS), National Institute of Advanced Industrial Science and Technology (AIST), 16-1 Onogawa, Tsukuba, Japan. Electronic address: n-shinohara@aist.go.jp., Oguri T; Research Institute of Science for Safety and Sustainability (RISS), National Institute of Advanced Industrial Science and Technology (AIST), 16-1 Onogawa, Tsukuba, Japan., Takagi M; Health and Environmental Risk Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Japan., Ueyama J; Graduate School of Medicine, Nagoya University, 1-1-20 Daikominami, Higashi-ku, Nagoya, Japan., Isobe T; Health and Environmental Risk Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Japan.
Jazyk: angličtina
Zdroj: Environment international [Environ Int] 2024 Jan; Vol. 183, pp. 108399. Date of Electronic Publication: 2023 Dec 22.
DOI: 10.1016/j.envint.2023.108399
Abstrakt: Phthalates are widely used as plasticizer and associated with various health issues. Recently, non-phthalate plasticizers are replacing phthalates; however, the exposure to these substances and the risk in Japan is unclear. In this study, we assessed the concentrations of phthalates, non-phthalate plasticizers, and phthalate degradation products in house dust and determined their respective exposure risks via oral and dermal routes. Twelve phthalates, seven non-phthalate plasticizers, and two degradation products were determined in the house dust obtained from 100 Japanese homes. The median concentration of di(2-ethylhexyl) phthalate (DEHP), accounting for 85 % of the total concentration of phthalates and non-phthalate plasticizers detected in this study, was 2.1 × 10 3 μg/g of dust. Apart from DEHP, diisononyl phthalate (DINP) and di(2-ethylhexyl) terephthalate (DEHT) were the most abundant in the house dust, accounting for 6.2 % (median: 1.7 × 10 2 μg/g of dust) and 6.1 % (median: 1.7 × 10 2 μg/g of dust) of the total concentrations, respectively. DEHP and DEHT concentrations in house dust were higher in apartment and small houses (floor area: ≤30 m 2 or 31-60 m 2 for DEHP and 31-60 m 2 for DEHT) than in detached and large houses (floor area: ≥121 m 2 ). Conversely, di-n-butyl phthalate (DnBP) concentrations were significantly higher in detached and large houses (floor area: ≥121 m 2 ) than in apartment and small houses (floor area: ≤30 m 2 ). The total hazard quotient (HQ), using the maximum concentration in house dust, revealed that oral and dermal exposure to house dust was 1.3 × 10 -6 -0.11 for adults (all substances) and 1.6 × 10 -5 -2.2 × 10 -2 for preschool children (except for DnBP and DEHP), suggesting no risk. The HQs for DnBP and DEHP exposure via house dust for preschool children using the maximum values were 0.46 and 1.2, and 6.0 × 10 -3 and 0.18 using the median values, indicating that risk of DEHP exposure should be exhaustively determined by considering other exposure routes that were not evaluated in this study, such as diet.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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