High-resolution myelin-water fraction and quantitative relaxation mapping using 3D ViSTa-MR fingerprinting.

Autor: Liao C; Department of Radiology, Stanford University, Stanford, California, USA.; Department of Electrical Engineering, Stanford University, Stanford, California, USA., Cao X; Department of Radiology, Stanford University, Stanford, California, USA.; Department of Electrical Engineering, Stanford University, Stanford, California, USA., Iyer SS; Department of Radiology, Stanford University, Stanford, California, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Schauman S; Department of Radiology, Stanford University, Stanford, California, USA.; Department of Electrical Engineering, Stanford University, Stanford, California, USA., Zhou Z; Department of Radiology, Stanford University, Stanford, California, USA.; Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China., Yan X; Department of Psychology, Stanford University, Stanford, California, USA.; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China., Chen Q; Department of Radiology, Stanford University, Stanford, California, USA.; Department of Electrical Engineering, Stanford University, Stanford, California, USA., Li Z; Department of Radiology, Stanford University, Stanford, California, USA., Wang N; Department of Radiology, Stanford University, Stanford, California, USA.; Department of Electrical Engineering, Stanford University, Stanford, California, USA., Gong T; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Wu Z; Techna Institute, University Health Network, Toronto, Ontario, Canada., He H; Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.; School of Physics, Zhejiang University, Hangzhou, China., Zhong J; Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.; Department of Imaging Sciences, University of Rochester, Rochester, New York, USA., Yang Y; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA., Kerr A; Department of Electrical Engineering, Stanford University, Stanford, California, USA.; Stanford Center for Cognitive and Neurobiological Imaging, Stanford University, Stanford, California, USA., Grill-Spector K; Department of Psychology, Stanford University, Stanford, California, USA., Setsompop K; Department of Radiology, Stanford University, Stanford, California, USA.; Department of Electrical Engineering, Stanford University, Stanford, California, USA.
Jazyk: angličtina
Zdroj: Magnetic resonance in medicine [Magn Reson Med] 2024 Jun; Vol. 91 (6), pp. 2278-2293. Date of Electronic Publication: 2023 Dec 29.
DOI: 10.1002/mrm.29990
Abstrakt: Purpose: This study aims to develop a high-resolution whole-brain multi-parametric quantitative MRI approach for simultaneous mapping of myelin-water fraction (MWF), T 1 , T 2 , and proton-density (PD), all within a clinically feasible scan time.
Methods: We developed 3D visualization of short transverse relaxation time component (ViSTa)-MRF, which combined ViSTa technique with MR fingerprinting (MRF), to achieve high-fidelity whole-brain MWF and T 1 /T 2 /PD mapping on a clinical 3T scanner. To achieve fast acquisition and memory-efficient reconstruction, the ViSTa-MRF sequence leverages an optimized 3D tiny-golden-angle-shuffling spiral-projection acquisition and joint spatial-temporal subspace reconstruction with optimized preconditioning algorithm. With the proposed ViSTa-MRF approach, high-fidelity direct MWF mapping was achieved without a need for multicompartment fitting that could introduce bias and/or noise from additional assumptions or priors.
Results: The in vivo results demonstrate the effectiveness of the proposed acquisition and reconstruction framework to provide fast multi-parametric mapping with high SNR and good quality. The in vivo results of 1 mm- and 0.66 mm-isotropic resolution datasets indicate that the MWF values measured by the proposed method are consistent with standard ViSTa results that are 30× slower with lower SNR. Furthermore, we applied the proposed method to enable 5-min whole-brain 1 mm-iso assessment of MWF and T 1 /T 2 /PD mappings for infant brain development and for post-mortem brain samples.
Conclusions: In this work, we have developed a 3D ViSTa-MRF technique that enables the acquisition of whole-brain MWF, quantitative T 1 , T 2 , and PD maps at 1 and 0.66 mm isotropic resolution in 5 and 15 min, respectively. This advancement allows for quantitative investigations of myelination changes in the brain.
(© 2023 International Society for Magnetic Resonance in Medicine.)
Databáze: MEDLINE
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