Does Indoxyl Sulfate Have a Role in Uremic Pruritus? A Laboratory and Interventional Study.
| Autor: | Akl EM; Department of Dermatology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt., El-Eraki JM; Specialist of Dermatology and Andrology, Ministry of Health and Population, Cairo, Egypt., Elfallah AA; Department of Clinical Pathology, Faculty of Medicine, Benha University, Benha, Egypt., Mohamed NH; Specialist of Clinical Pathology, Ministry of Health and Population, Benha, Egypt., Maher AM; Specialist of Internal Medicine, Ministry of Health and Population, Cairo, Egypt., Mansour AE; Department of Internal Medicine, Faculty of Medicine, Benha University, Benha, Egypt., Abdelsalam OH; Department of Dermatology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of cutaneous medicine and surgery [J Cutan Med Surg] 2024 Jan-Feb; Vol. 28 (1), pp. 44-50. Date of Electronic Publication: 2023 Dec 29. |
| DOI: | 10.1177/12034754231220935 |
| Abstrakt: | Background: Pruritus is a common complaint in patients with end-stage renal disease. Indoxyl sulfate (IS) is a tryptophan end metabolite extremely renal excreted. Activated charcoal can interfere with IS intestinal absorption. Objectives: To evaluate the serum level of IS and the effect of activated charcoal on uremic pruritus. Materials and Methods: In all, 135 participants were divided into 2 main groups. In total, 45 normal and healthy individuals as a control group and 90 patients on regular hemodialysis; 45 of these patients had uremic pruritus and the other 45 were not complaining of uremic pruritus. Serum IS was measured. Activated charcoal was used by patients with uremic pruritus. The severity of pruritus and Dermatology Life Quality Index (DLQI) were assessed. Results: The serum IS was significantly elevated in uremic patients than in control subjects ( P < .001) and significantly elevated in uremic patients without pruritus ( P < .001). Furthermore, there were positive significant correlations between the serum IS and both severity of pruritus ( P < .001) and DLQI ( P < .001). After activated charcoal usage, there was a significant decrease in IS level with the improvement of pruritus and quality of life of patients. Conclusions: IS may play a role in uremic pruritus. Activated charcoal could be considered a treatment for uremic pruritus. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Databáze: | MEDLINE |
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