Distribution of human gene polymorphisms allele frequencies associated with viral infections.

Autor:	Vlasenko NV; Central Research Institute for Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing., Chanyshev MD; Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing., Dubodelov DV; Central Research Institute for Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing., Serkov AA; Central Research Institute for Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing., Solopova GG; Dmitry Rogachev National Medical Research Center of Pediatric Hematology., Sacuk AV; Dmitry Rogachev National Medical Research Center of Pediatric Hematology., Snicar AV; Demikhov Moscow City Clinical Hospital., Semenenko TА; N.F. Gamaleya National Research Center of Epidemiology and Microbiology., Kuzin SN; Central Research Institute for Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing., Akimkin VG; Central Research Institute for Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing.
Jazyk:	angličtina
Zdroj:	Voprosy virusologii [Vopr Virusol] 2023 Nov 07; Vol. 68 (5), pp. 404-414. Date of Electronic Publication: 2023 Nov 07.
DOI:	10.36233/0507-4088-189
Abstrakt:	Introduction: The design of studies aimed at finding the association between the genetic factor and the studied feature (disease) involves a comparison of the ratio of genotypes or allelic proportions in the study group with those in the control group. At the stage of determining the ratio of genotypes of the studied polymorphisms in the reference group, researchers meet a number of problems, which are the subject of the present work. Aim of the work is to provide scientific rationale for the feasibility of creating a national information system comprising genetic data of the relatively healthy population of Russia, incorporating its ethnic diversity. Materials and Methods: The study group, total 1020 people, was genotyped for a number of single nucleotide polymorphisms of human genes. A comparative characteristic of the frequency distribution of the studied polymorphisms with those presented in international databases as reference data was carried out using χ 2 index. Results: The frequency of SNP rs4986790 of the TLR 4 gene significantly differs from the EUR population ( p = 0.032) and the CEU subpopulation ( p = 0.047). The allele frequencies of the rs1800795 ( IL 6 ) and rs1800896 ( IL 10 ) polymorphisms in the study population differ from the CEU subgroup ( p = 0.030 and 0.012, respectively). The frequency of SNP rs2295119 ( HLA - DPA 2 ) in the study group is significantly different from the EUR population ( p = 0.034). Conclusion: The analysis carried out in this work confirms the need to create a domestic information system containing data on the occurrence of SNP alleles and genotypes for a conditionally healthy population and in subgroups with various pathological conditions.
Databáze:	MEDLINE
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