Correlation of Beta Trace Protein Levels with Serum Creatinine-Based Estimated Glomerular Filtration Rate Equations in Chronic Kidney Disease.

Autor:	Geethanjali R; Department of Biochemistry, Government Medical College, Thiruvallur, India., Ganesh M; Department of Biochemistry, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai., Vinod A; Department of Biochemistry, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai., Ramprasad E; Department of Nephrology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai., Jayaprakash V; Department of Nephrology, SRM Medical College Hospital and Research Centre, SRM IST, Chengalpattu Dt, India.
Jazyk:	angličtina
Zdroj:	Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia [G Ital Nefrol] 2023 Dec 22; Vol. 40 (6). Date of Electronic Publication: 2023 Dec 22.
Abstrakt:	Background. Estimated GFR (eGFR) is calculated using serum creatinine (SCr) based equations which have their own limitations. Novel biomarkers like beta trace protein (BTP) are studied for eGFR estimation. The aim of this study is to determine the serum levels of BTP in healthy controls and chronic kidney disease (CKD) cases and to find out the correlation of BTP levels with that of SCr and SCr-based eGFR formulas. Methods. The control group comprised of 20 healthy adults. The cases comprised of 20 patients each in CKD stages 3, 4, and 5, categorized based on eGFR calculated using MDRD formula. Baseline characteristics of the study population were recorded. BTP was measured by ELISA (Enzyme Linked Immunosorbent Assay) method and SCr by modified Jaffe's method. The statistical analyses were performed with the SPSS for Windows, version 16.0. Results. The median value of blood urea nitrogen (BUN) in the cases was 26.50 mg/dL (IQR 19.25-37) and for control it was 9.5 mg/dL (IQR 8-12). The median value of SCr in the cases was 2.75 mg/dL (IQR 1.725-4.45) and in the controls, it was 0.7mg/dL (IQR 0.6 -0.8). The median value of BTP in cases was 6389.25 ng/ml (IQR 5610.875-10713.75) and in controls, it was 1089.5 ng/ml (IQR 900.5-1309.75). Conclusion. Serum BTP levels correlated with SCr levels and renal function. We could establish the relationship between the two biomarkers, SCr and BTP, and derive a regression equation. (Copyright by Società Italiana di Nefrologia SIN, Rome,Italy.)
Databáze:	MEDLINE
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