Effects of secretin gene knockout on the diversity, composition, and function of gut microbiota in adult male mice.
| Autor: | Zhang F; School of Biological Sciences, The University of Hong Kong, Hong Kong, Hong Kong SAR, China., Tao Z; School of Biological Sciences, The University of Hong Kong, Hong Kong, Hong Kong SAR, China., Chen C; School of Biological Sciences, The University of Hong Kong, Hong Kong, Hong Kong SAR, China., Chow BKC; School of Biological Sciences, The University of Hong Kong, Hong Kong, Hong Kong SAR, China. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2023 Dec 13; Vol. 13, pp. 1257857. Date of Electronic Publication: 2023 Dec 13 (Print Publication: 2023). |
| DOI: | 10.3389/fcimb.2023.1257857 |
| Abstrakt: | The gut microbiota plays a vital role in maintaining gastrointestinal homeostasis, however, whether it is influenced by gut hormones remains unknown. Secretin is a well-known gastrointestinal hormone produced by enteroendocrine S cells. This study utilized 16S rRNA amplicon sequencing to characterize the effect of SCT deficiency on the gut microbiota. Our results show that systemic SCT knockout alters the composition and abundance of the mouse gut microbiota but does not affect fecal short-chain fatty acids and lipids concentrations. At the genus level, the abundance of Turicibacter , Bacteroides , Ruminococcu , Romboutsia , Asaccharobacter , and Parasutterella increased in SCT -/- mice, whereas the abundance of Akkermansia and Escherichia decreased. Functional prediction results showed that lack of SCT reduced the abundance of carbohydrate metabolism-related pathways but increased the abundance of linoleic acid metabolism and branched-chain amino acid degradation. Overall, systemic SCT knockout had only minor effects on gut microbiota composition and function in adult male mice fed a standard chow diet. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Zhang, Tao, Chen and Chow.) |
| Databáze: | MEDLINE |
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