Sex-dimorphism in human serum endocannabinoid and n-acyl ethanolamine concentrations across the lifespan.

Autor: Amir Hamzah K; School of Psychology and Counselling, Faculty of Health, Queensland University of Technology, 149 Victoria Park Road, Kelvin Grove, Brisbane, 4059, Australia. khalisa.amirhamzah@gmail.com., Toms LM; School of Public Health and Social Work, Faculty of Health, Queensland University of Technology, Kelvin Grove, Australia., Kucharski N; School of Public Health and Social Work, Faculty of Health, Queensland University of Technology, Kelvin Grove, Australia., Orr J; The University of Queensland, Queensland Alliance for Environmental Health Sciences, Woolloongabba, QLD, Australia., Turner NP; The Centre for Children's Health Research (CCHR), Queensland University of Technology, 62 Graham Street, South Brisbane, QLD, 4101, Australia., Hobson P; The University of Queensland, Queensland Alliance for Environmental Health Sciences, Woolloongabba, QLD, Australia.; Sullivan and Nicolaides Pathology, 24 Hurworth Street, Bowen Hills, QLD, 4006, Australia., Nichols DS; Central Science Laboratory, University of Tasmania, Sydney, Australia., Ney LJ; School of Psychology and Counselling, Faculty of Health, Queensland University of Technology, 149 Victoria Park Road, Kelvin Grove, Brisbane, 4059, Australia.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Dec 27; Vol. 13 (1), pp. 23059. Date of Electronic Publication: 2023 Dec 27.
DOI: 10.1038/s41598-023-50426-4
Abstrakt: The endocannabinoid (ECB) system has recently been considered a potential treatment target for various clinical disorders. However, research around age- and sex-related changes within the ECB system is relatively limited. To improve our understanding of these changes, the current study measured arachidonoyl ethanolamide (AEA), 2-arachidonoyl glycerol (2-AG), oleoylethanolamine (OEA), palmitoylethanolamine (PEA), arachidonic acid (AA), cortisol, and progesterone in pooled serum samples stratified by sex (male and female) and age groups (5-15; 15-30; 30-45; 45-60; 60-75; 85+), using liquid-chromatography tandem mass spectrometry. Serum progesterone levels significantly increased in females of the 15-30 and 30-45 age groups, before declining. Significantly higher cortisol, AEA, 2-AG, OEA, and PEA were found in males and in older age, while significantly higher AA was found in females. Our results indicate that ECBs and related hormones exhibit sexual dimorphism in the age ranges that correspond with female pregnancy, menopause, and post menopause. Male testosterone levels most likely influences male ECB changes throughout the lifespan. Future research could capitalise on these findings by performing repeated measurements in individuals in a longitudinal style, to further refine the temporal profile of age-specific changes to the ECB system identified here.
(© 2024. The Author(s).)
Databáze: MEDLINE
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