Gut microbiome responds to alteration in female sex hormone status and exacerbates metabolic dysfunction.

Autor: Cross TL; Department of Nutrition Science, Purdue University, West Lafayette, IN, USA.; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Department of Animal Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.; Cardiovascular Research Center, University of Wisconsin-Madison, Madison, WI, USA., Simpson AMR; Department of Nutrition Science, Purdue University, West Lafayette, IN, USA., Lin CY; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA., Hottmann NM; Department of Animal Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA., Bhatt AP; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Pellock SJ; Departments of Biochemistry & Biophysics, Microbiology & Immunology, and The Integrated Program for Biological and Genome Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Nelson ER; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Cancer Center at Illinois, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology-Anticancer Discovery from Pets to People, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, USA., Loman BR; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Department of Animal Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA., Wallig MA; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA., Vivas EI; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA., Suchodolski J; Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA., Redinbo MR; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA.; Departments of Biochemistry & Biophysics, Microbiology & Immunology, and The Integrated Program for Biological and Genome Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Rey FE; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.; Cardiovascular Research Center, University of Wisconsin-Madison, Madison, WI, USA., Swanson KS; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Department of Animal Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Jazyk: angličtina
Zdroj: Gut microbes [Gut Microbes] 2024 Jan-Dec; Vol. 16 (1), pp. 2295429. Date of Electronic Publication: 2023 Dec 28.
DOI: 10.1080/19490976.2023.2295429
Abstrakt: Women are at significantly greater risk of metabolic dysfunction after menopause, which subsequently leads to numerous chronic illnesses. The gut microbiome is associated with obesity and metabolic dysfunction, but its interaction with female sex hormone status and the resulting impact on host metabolism remains unclear. Herein, we characterized inflammatory and metabolic phenotypes as well as the gut microbiome associated with ovariectomy and high-fat diet feeding, compared to gonadal intact and low-fat diet controls. We then performed fecal microbiota transplantation (FMT) using gnotobiotic mice to identify the impact of ovariectomy-associated gut microbiome on inflammatory and metabolic outcomes. We demonstrated that ovariectomy led to greater gastrointestinal permeability and inflammation of the gut and metabolic organs, and that a high-fat diet exacerbated these phenotypes. Ovariectomy also led to alteration of the gut microbiome, including greater fecal β-glucuronidase activity. However, differential changes in the gut microbiome only occurred when fed a low-fat diet, not the high-fat diet. Gnotobiotic mice that received the gut microbiome from ovariectomized mice fed the low-fat diet had greater weight gain and hepatic gene expression related to metabolic dysfunction and inflammation than those that received intact sham control-associated microbiome. These results indicate that the gut microbiome responds to alterations in female sex hormone status and contributes to metabolic dysfunction. Identifying and developing gut microbiome-targeted modulators to regulate sex hormones may be useful therapeutically in remediating menopause-related diseases.
Databáze: MEDLINE