Exploring the microbial landscape: uncovering the pathogens associated with community-acquired pneumonia in hospitalized patients.

Autor:	Hansen K; Clinical Microbiology, Department of Translational Medicine, Faculty of Medicine Lund University, Malmö, Sweden.; Infectious Diseases, Department of Translational Medicine, Faculty of Medicine Lund University, Malmö, Sweden., Yamba Yamba L; Clinical Microbiology, Department of Translational Medicine, Faculty of Medicine Lund University, Malmö, Sweden., Wasserstrom L; Clinical Microbiology, Department of Translational Medicine, Faculty of Medicine Lund University, Malmö, Sweden.; Clinical Microbiology, Infection Control and Prevention, Laboratory Medicine, Lund, Sweden., Rünow E; Clinical Microbiology, Department of Translational Medicine, Faculty of Medicine Lund University, Malmö, Sweden.; Infectious Diseases, Department of Translational Medicine, Faculty of Medicine Lund University, Malmö, Sweden., Göransson T; Clinical Microbiology, Infection Control and Prevention, Laboratory Medicine, Lund, Sweden., Nilsson A; Infectious Diseases, Department of Translational Medicine, Faculty of Medicine Lund University, Malmö, Sweden., Ahl J; Clinical Microbiology, Department of Translational Medicine, Faculty of Medicine Lund University, Malmö, Sweden.; Infectious Diseases, Department of Translational Medicine, Faculty of Medicine Lund University, Malmö, Sweden., Riesbeck K; Clinical Microbiology, Department of Translational Medicine, Faculty of Medicine Lund University, Malmö, Sweden.; Clinical Microbiology, Infection Control and Prevention, Laboratory Medicine, Lund, Sweden.
Jazyk:	angličtina
Zdroj:	Frontiers in public health [Front Public Health] 2023 Dec 13; Vol. 11, pp. 1258981. Date of Electronic Publication: 2023 Dec 13 (Print Publication: 2023).
DOI:	10.3389/fpubh.2023.1258981
Abstrakt:	Objectives: This study aimed to investigate the etiology, clinical features, and outcomes of community-acquired pneumonia (CAP) in adults. Understanding the causative pathogens is essential for effective treatment and prevention. Design: Between 2016-2018, 518 hospitalized adults with CAP and 241 controls without symptoms were prospectively enrolled. Urine samples were collected for pneumococcal urinary antigen tests and nasopharyngeal swabs for viral and bacterial analysis, combined with routine diagnostic care. Results: Among the included CAP patients, Streptococcus pneumoniae was the most common pathogen, detected in 28% of patients, followed by Haemophilus influenzae in 16%. Viruses were identified in 28%, and concurrent viruses and bacteria were detected in 15%. There was no difference in mortality, length of stay, or symptoms at hospitalization when comparing patients with bacterial, viral, or mixed etiologies. Among the control subjects without respiratory symptoms, S. pneumoniae , H. influenzae , or Moraxella catarrhalis were detected in 5-7%, and viruses in 7%. Conclusion: Streptococcus pneumoniae emerged as the predominant cause of CAP, followed closely by viruses and H. influenzae . Intriguingly, symptoms and outcome were similar regardless of etiology. These findings highlight the complexity of this respiratory infection and emphasize the importance of comprehensive diagnostic and treatment strategies. Clinical Trial Registration : ClinicalTrials.gov, identifier [NCT03606135]. Competing Interests: KR reports an unrestricted grant from Pfizer during the conduct of the study outside the submitted work. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Hansen, Yamba Yamba, Wasserstrom, Rünow, Göransson, Nilsson, Ahl and Riesbeck.)
Databáze:	MEDLINE
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