Interleukin 33, soluble suppression of tumorigenicity 2, interleukin 27, and galectin 3 as predictors for outcome in patients admitted to intensive care units.

Autor:	Eric S; Department of Anesthesiology and Reanimation, University Clinical Center Kragujevac, Kragujevac, Serbia.; Department of Surgery, Faculty of Medical Sciences, University Clinical Center Kragujevac, Kragujevac, Serbia., Zaric RZ; Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia., Jevdjic J; Department of Anesthesiology and Reanimation, University Clinical Center Kragujevac, Kragujevac, Serbia.; Department of Surgery, Faculty of Medical Sciences, University Clinical Center Kragujevac, Kragujevac, Serbia., Drakulic SM; Department of Neurology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia., Stanojevic I; Faculty of Medicine of the Military Medical Academy, University of Defense, Belgrade, Serbia.; Insitute for Medical Research, Military Medical Academy, Belgrade, Serbia., Vojvodic D; Faculty of Medicine of the Military Medical Academy, University of Defense, Belgrade, Serbia.; Insitute for Medical Research, Military Medical Academy, Belgrade, Serbia., Arsenijevic P; Department of Gynecology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia., Stojanovic B; Department of Surgery, Faculty of Medical Sciences, University Clinical Center Kragujevac, Kragujevac, Serbia., Jakovljevic S; Department of Surgery, Faculty of Medical Sciences, University Clinical Center Kragujevac, Kragujevac, Serbia., Markovic N; Department of Surgery, Faculty of Medical Sciences, University Clinical Center Kragujevac, Kragujevac, Serbia., Zaric M; Department of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia., Canovic P; Department of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia., Nesic J; Department of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.; Department of Endocrinology, University Clinical Center Kragujevac, Kragujevac, Serbia., Zornic N; Department of Anesthesiology and Reanimation, University Clinical Center Kragujevac, Kragujevac, Serbia.; Department of Surgery, Faculty of Medical Sciences, University Clinical Center Kragujevac, Kragujevac, Serbia.
Jazyk:	angličtina
Zdroj:	Open medicine (Warsaw, Poland) [Open Med (Wars)] 2023 Dec 21; Vol. 18 (1), pp. 20230859. Date of Electronic Publication: 2023 Dec 21 (Print Publication: 2023).
DOI:	10.1515/med-2023-0859
Abstrakt:	Intensive care units (ICUs) are expert hospital areas that provide treatment and 24 h care for people who are very sick. Sepsis represents a serious, severe condition and it can lead to septic shock and multiple organ dysfunction syndromes and is one of the most common reasons for patients' hospitalization in ICUs. We wanted to explore the prognostic values of interleukin (IL) 33, soluble suppression of tumorigenicity 2 (sST2), IL 27, and galectin 3 in critically-ill patients. We assumed that these parameters in combination or alone could predict mortality in ICU patients. This research represents a clinical non-randomized prospective study, performed at the Medical Military Academy, a tertiary care hospital in Belgrade, Serbia. The patients were divided in four groups: patients with sepsis (peritonitis, pancreatitis, trauma) and patients without sepsis (trauma). Total number of patients enrolled in the study was 151 and average years of patients were 56.48. The values greater than the cut-off were the predictors of mortality. The IL-33, IL-27 as well as galectin-3 can successfully predict the outcome of critically-ill patients in ICUs. The sST2, cannot predict death in critically-ill patients as a single prognostic factor. However, the combination of at least two biomarkers: IL-33, sST2, IL-27, and galectin-3, gives very significant results in predicting the outcome in patients admitted to ICUs. Competing Interests: Conflict of interest: Authors state no conflict of interest. (© 2023 the author(s), published by De Gruyter.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu