A role for Shugoshin in human cilia?
| Autor: | Reed R; Biology, Department of Biology, University of Saskatchewan., Nyarko JNK; Department of Psychiatry & Physiology, University of Saskatchewan., Mousseau DD; Department of Psychiatry & Physiology, University of Saskatchewan., Egydio de Carvalho C; Department of Biology, Department of Biology, University of Saskatchewan. |
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| Jazyk: | angličtina |
| Zdroj: | MicroPublication biology [MicroPubl Biol] 2023 Dec 12; Vol. 2023. Date of Electronic Publication: 2023 Dec 12 (Print Publication: 2023). |
| DOI: | 10.17912/micropub.biology.001013 |
| Abstrakt: | We have recently described a novel role for the conserved centromeric/kinetochore protein and cohesin protector, Shugoshin, in cilia of C. elegans. Worms are unusual in that the sole Shugoshin protein ( SGO-1 ) is dispensable for chromosome segregation but required for cilia function in fully differentiated sensory neurons. Depletion of sgo-1 leads to an array of sensory defects observed in other cilia mutants with a compromised diffusion barrier. Accordingly, SGO-1 loads to the base of cilia in sensory neurons and can be observed occupying the transition zone, the critical ciliary domain that regulates trafficking in and out of ciliary compartments. Here we start to address a potential conserved role in cilia for vertebrate Shugoshin by asking whether human Shugoshin can: (1) localize to cilia and (2) rescue defects due to Shugoshin depletion in C. elegans . Our preliminary results suggest that human Shugoshin is detectable in the cilia base but show limited functional conservation when expressed in C. elegans sensory neurons. Competing Interests: The authors declare that there are no conflicts of interest present. (Copyright: © 2023 by the authors.) |
| Databáze: | MEDLINE |
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