Potentially functional genetic variants in ferroptosis-related CREB3 and GALNT14 genes predict survival of hepatitis B virus-related hepatocellular carcinoma.

Autor:	Zhan S; Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning, China.; Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, China., Qiu M; Department of Respiratory Oncology, Guangxi Medical University Cancer Hospital, Nanning, China., Wei X; Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning, China.; Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, China., Wei J; Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning, China.; Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, China., Qin L; Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning, China.; Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, China., Jiang B; Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning, China., Wen Q; Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning, China., Chen P; Editorial Department of Chinese Journal of Oncology Prevention and Treatment, Guangxi Medical University Cancer Hospital, Nanning, China., Lin Q; Department of Clinical Research, Guangxi Medical University Cancer Hospital, Nanning, China., Wei X; Department of Clinical Research, Guangxi Medical University Cancer Hospital, Nanning, China., Zhou Z; Department of Cancer Prevention and Control, Guangxi Medical University Cancer Hospital, Nanning, China., Jiang Y; Scientific Research Department, Guangxi Medical University Cancer Hospital, Nanning, China., Liang X; Department of Disease Process Management, Guangxi Medical University Cancer Hospital, Nanning, China., Li R; Department of Civil Engineering, College of Engineering, New Mexico State University, Las Cruces, New Mexico, USA., Liu Y; Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning, China.; Key Cultivated Laboratory of Cancer Molecular Medicine of Guangxi Health Commission, Guangxi Medical University Cancer Hospital, Nanning, China., Yu H; Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning, China.; Key Cultivated Laboratory of Cancer Molecular Medicine of Guangxi Health Commission, Guangxi Medical University Cancer Hospital, Nanning, China.; Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning, China.
Jazyk:	angličtina
Zdroj:	Cancer medicine [Cancer Med] 2024 Jan; Vol. 13 (1), pp. e6848. Date of Electronic Publication: 2023 Dec 27.
DOI:	10.1002/cam4.6848
Abstrakt:	Background: Ferroptosis is a known crucial player in the development of cancers. However, the effect of single nucleotide polymorphisms (SNPs) in ferroptosis-related genes on survival in hepatitis B virus (HBV)-related hepatocellular carcinoma (HBV-HCC) patients remains unknown. Methods: We used two-stage multivariable Cox proportional hazards regression analyses to estimate the associations between 48,774 SNPs in 480 ferroptosis-related genes and overall survival (OS) of 866 HBV-HCC patients. Results: We identified that two potentially functional SNPs (CREB3 rs10814274 C > T and GALNT14 rs17010547 T > C) were significantly independently associated with the OS of HBV-HCC patients (CT + TT verse CC, hazards ratio (HR) = 0.77, 95% confidence interval (CI) = 0.67-0.89, p < 0.001 for rs10814274 and TC + CC verse TT, HR = 0.66, 95% CI = 0.53-0.82, p < 0.001 for rs17010547, respectively). Additional joint assessment of protective genotypes of these two SNPs showed that patients with 1-2 protective genotypes had a significantly better OS compared with those carrying 0 protective genotypes (HR = 0.56, 95% CI = 0.45-0.70, p < 0.001). Moreover, the expression quantitative trait loci (eQTL) analysis revealed that the survival-associated SNP rs10814274 T allele was significantly correlated with reduced CREB3 transcript levels in both normal liver tissues and whole blood cells, while the GALNT14 rs17010547 C allele had a significant correlation with increased GALNT14 transcript levels in whole blood cells. Conclusion: These results suggest that genetic variants of CREB3 and GALNT14 may affect the survival of HBV-HCC patients, likely via transcriptional regulation of respective genes. However, further studies are required to confirm these findings. (© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu PDF