Lumbar vertebral bone density is decreased in horses with pituitary pars intermedia dysfunction.

Autor: Colbath AC; Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA., Fortin JS; Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA., Burglass CM; Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA., Panek C; Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA., Vergara-Hernandez FB; Animal Sciences, College of Agriculture and Natural Resources, Michigan State University, East Lansing, Michigan, USA., Johnson TN; Chemical Engineering and Materials Science, College of Engineering, Michigan State University, East Lansing, Michigan, USA., Robison CA; Animal Sciences, College of Agriculture and Natural Resources, Michigan State University, East Lansing, Michigan, USA., Logan AA; Animal Sciences, College of Agriculture and Natural Resources, Michigan State University, East Lansing, Michigan, USA., Nelson NA; Molecular Biologic Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA., Nielsen BD; Animal Sciences, College of Agriculture and Natural Resources, Michigan State University, East Lansing, Michigan, USA., Schott HC 2nd; Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Jazyk: angličtina
Zdroj: Equine veterinary journal [Equine Vet J] 2024 Mar; Vol. 56 (2), pp. 368-376. Date of Electronic Publication: 2023 Dec 27.
DOI: 10.1111/evj.14039
Abstrakt: Background: Pathological fractures have been reported in equids with pituitary pars intermedia dysfunction (PPID) but their prevalence and pathogenesis is unknown.
Objectives: To compare: (1) bone mineral density (BMD) in weight bearing and nonweight bearing bones in PPID + equids and aged and young PPID - controls; and (2) biomechanical properties of the fourth lumbar vertebral body in PPID + equids and aged PPID - equids.
Study Design: Case-control study: five PPID + equids and six aged and four young PPID - control horses.
Methods: PPID status was based on clinical signs and necropsy examination of the pituitary gland (PG). The lumbar vertebral column, right front third metacarpus (MC3), left hind third metatarsus (MT3), and PG were removed after euthanasia. BMD was determined by quantitative computed tomography of regions of interest (ROI) in each bone and biomechanical testing was performed on the fourth lumbar vertebral body. Serum concentrations of parathormone (PTH), ionised Ca ++ , 25-hydroxyvitamin D, and osteocalcin (OC) were also measured. Data were analysed using one-way ANOVA and correlation analyses.
Results: BMD of trabecular and cortical regions of interest (ROI) of the third, fourth (L4), and fifth lumbar vertebrae were significantly lower in PPID + equids as compared with aged (p < 0. 001) and young (p < 0.01) PPID - controls. In contrast, no differences were found in BMD of trabecular or cortical ROIs of MC3 and MT3 between groups. No differences were detected in force at fracture, displacement at fracture, Young's modulus or strain of L4 between PPID + and aged PPID - horses. No differences were found in serum PTH, ionised Ca ++ , 25-hydroxyvitamin D, or OC concentrations between groups.
Main Limitations: Limited number of equids studied and variation in test results.
Conclusions: BMD of nonweight bearing bones can be decreased with PPID and could increase risk of developing pathological fractures.
(© 2023 The Authors. Equine Veterinary Journal published by John Wiley & Sons Ltd on behalf of EVJ Ltd.)
Databáze: MEDLINE
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