Prevalence of neoplasia at colonoscopy among testicular cancer survivors treated with platinum-based chemotherapy.

Autor: Breekveldt ECH; Department of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands., Ykema BLM; Department of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Bisseling TM; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands., Moons LMG; Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands., Spaander MCW; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands., Huibregtse IL; Department of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., van der Biessen-van Beek DTJ; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands., Mulder SF; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands., Saveur L; Department of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Kerst JM; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Zweers D; Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Suelmann BBM; Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., de Wit R; Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands., Reijm A; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands., van Baalen S; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands., Butterly LF; Department of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.; NH Colonoscopy Registry, Lebanon, New Hampshire, USA., Hisey WM; Department of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.; NH Colonoscopy Registry, Lebanon, New Hampshire, USA., Robinson CM; Department of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.; NH Colonoscopy Registry, Lebanon, New Hampshire, USA., van Vuuren AJ; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands., Carvalho B; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Lansdorp-Vogelaar I; Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands., Schaapveld M; Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands., van Leeuwen FE; Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Snaebjornsson P; Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands.; University of Iceland, Faculty of Medicine, Reykjavik, Iceland., van Leerdam ME; Department of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.
Jazyk: angličtina
Zdroj: International journal of cancer [Int J Cancer] 2024 Apr 15; Vol. 154 (8), pp. 1474-1483. Date of Electronic Publication: 2023 Dec 27.
DOI: 10.1002/ijc.34810
Abstrakt: Testicular cancer survivors (TCS) treated with platinum-based chemotherapy have an increased risk of colorectal cancer (CRC). We determined the yield of colonoscopy in TCS to assess its potential in reducing CRC incidence and mortality. We conducted a colonoscopy screening study among TCS in four Dutch hospitals to assess the yield of colorectal neoplasia. Neoplasia was defined as adenomas, serrated polyps (SPs), advanced adenomas (AAs: ≥10 mm diameter, high-grade dysplasia or ≥25% villous component), advanced serrated polyps (ASPs: ≥10 mm diameter or dysplasia) or CRC. Advanced neoplasia (AN) was defined as AA, ASP or CRC. Colonoscopy yield was compared to average-risk American males who underwent screening colonoscopy (n = 24,193) using a propensity score matched analysis, adjusted for age, smoking status, alcohol consumption and body mass index. A total of 137 TCS underwent colonoscopy. Median age was 50 years among TCS (IQR 43-57) vs 55 years (IQR 51-62) among American controls. A total of 126 TCS were matched to 602 controls. The prevalence of AN was higher in TCS than in controls (8.7% vs 1.7%; P = .0002). Nonadvanced adenomas and SPs were detected in 45.2% of TCS vs 5.5% of controls (P < .0001). No lesions were detected in 46.0% of TCS vs 92.9% of controls (P < .0001). TCS treated with platinum-based chemotherapy have a higher prevalence of neoplasia and AN than matched controls. These results support our hypothesis that platinum-based chemotherapy increases the risk of colorectal neoplasia in TCS. Cost-effectiveness studies are warranted to ascertain the threshold of AN prevalence that justifies the recommendation of colonoscopy for TCS.
(© 2023 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.)
Databáze: MEDLINE
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