Transdiagnostic inflammatory and oxidative biomarkers with predictive capacity of self-injurious behavior in impulsive and unstable disorders.

Autor: López-Villatoro JM; Institute of Health Research, Hospital Clínico San Carlos (IdISSC), Madrid, Spain; Department of Psychiatry and Medical Psychology, Faculty of Medicine, UCM, Madrid, Spain. Electronic address: jolope09@ucm.es., De la Torre-Luque A; Biomedical Research Networking Consortium for Mental Health (CIBERSAM), Madrid, Spain; Department of Psychiatry and Medical Psychology, Faculty of Medicine, UCM, Madrid, Spain., MacDowell KS; Department of Pharmacology and Toxicology, Faculty of Medicine, University Complutense de Madrid (UCM), Institute of Health Research Hospital 12 de Octubre (imas12), University Institute of Research in Neurochemistry UCM, Madrid, Spain; Biomedical Research Networking Consortium for Mental Health (CIBERSAM), Madrid, Spain., Galvez-Merlin A; Department of Psychiatry and Medical Psychology, Faculty of Medicine, UCM, Madrid, Spain., Gómez Del Barrio A; Biomedical Research Networking Consortium for Mental Health (CIBERSAM), Madrid, Spain; Marqués de Valdecilla University Hospital, Eating Disorders Unit, Department of Psychiatry, Santander, Spain; Valdecilla Biomedical Research Institute (IDIVAL), Santander, Spain., Beato-Fernández L; General Hospital of Ciudad Real, Ciudad Real, Spain., Ruiz-Guerrero F; Marqués de Valdecilla University Hospital, Eating Disorders Unit, Department of Psychiatry, Santander, Spain; Valdecilla Biomedical Research Institute (IDIVAL), Santander, Spain., Mola-Cardenes P; Institute of Health Research, Hospital Clínico San Carlos (IdISSC), Madrid, Spain., Polo-Montes F; General Hospital of Ciudad Real, Ciudad Real, Spain., León-Velasco M; General Hospital of Ciudad Real, Ciudad Real, Spain., Castro-Fuentes L; Marqués de Valdecilla University Hospital, Eating Disorders Unit, Department of Psychiatry, Santander, Spain., Leza JC; Department of Pharmacology and Toxicology, Faculty of Medicine, University Complutense de Madrid (UCM), Institute of Health Research Hospital 12 de Octubre (imas12), University Institute of Research in Neurochemistry UCM, Madrid, Spain; Biomedical Research Networking Consortium for Mental Health (CIBERSAM), Madrid, Spain., Carrasco JL; Biomedical Research Networking Consortium for Mental Health (CIBERSAM), Madrid, Spain; Department of Psychiatry and Medical Psychology, Faculty of Medicine, UCM, Madrid, Spain., Díaz-Marsá M; Biomedical Research Networking Consortium for Mental Health (CIBERSAM), Madrid, Spain; Department of Psychiatry and Medical Psychology, Faculty of Medicine, UCM, Madrid, Spain.
Jazyk: angličtina
Zdroj: Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2024 Mar 02; Vol. 130, pp. 110927. Date of Electronic Publication: 2023 Dec 25.
DOI: 10.1016/j.pnpbp.2023.110927
Abstrakt: Introduction: Alterations in inflammatory processes have previously been reported in impulsive and unstable disorders, as well as in other psychiatric conditions. In order to investigate transdiagnostic biomarkers associated with various phenotypic features of these disorders, this study is designed to identify biomarkers of inflammatory and oxidative endophenotypes related to autolytic behavior.
Methods: Peripheral blood mononuclear cells were collected from 35 patients with borderline personality disorder (BPD), 29 patients with restrictive eating disorder (rED), 21 patients with purging eating disorder (pED) and 23 control subjects. Plasma levels of different inflammatory and oxidative factors were measured by ELISA and the expression of selected proteins was by Western Blot. Principal component analysis (PCA) was performed to categorize the different inflammatory factors. Additionally, Ancova was performed to observe the differences in the principal components among the different groups and logistic regression analysis was conducted to assess the predictive capacity of these components for autolytic behaviors.
Results: We found two inflammatory/oxidative components were associated with BPD, characterized by high levels of JNK and ERK and low levels of GPx, SOD and Keap1; and two other inflammatory/oxidative components were linked to pED, associated with more JNK, TBARS and TNF-α and less GPx and SOD. Two components, with more JNK and ERK and less GPx, SOD and Keap1, predicted non-suicidal self-injury and three components, with higher JNK, TBARS and TNF-α levels and lower GPx, SOD and iNOS levels, predicted suicide attempts.
Conclusions: These results strongly support the endophenotypic characterization of impulsivity and the identification of transdiagnostic inflammatory/oxidative biomarkers relevant to autolytic behavior in impulsive and unstable disorders. These dates lay the groundwork for developing of screening tests for these biomarker components to rapidly detect biological risk factors for specific impulse control disorders and future self-injurious behaviors.
Competing Interests: Declaration of Competing Interest This work was supported by the PI20/01471 and PI16/01949 projects, integrated in the Plan National de I + D + I, AES 20–23 and 16–19 respectively; funded by the ISCIII and co-funded by the European Regional Development Fund (ERDF). “A way to make Europe”.
(Copyright © 2023. Published by Elsevier Inc.)
Databáze: MEDLINE
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