Reductions in WHO risk drinking levels correlate with alcohol craving among individuals with alcohol use disorder.

Autor: Tuchman FR; Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA., Hallgren KA; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA., Richards DK; Center on Alcohol, Substance use, and Addictions (CASAA), University of New Mexico, Albuquerque, New Mexico, USA., Aldridge A; Behavioral Health Financing, Economics and Evaluation Department, Research Triangle Institute (RTI) International, Durham, North Carolina, USA., Anton RF; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA., Aubin HJ; AP-HP, Université Paris Saclay, French Institute of Health and Medical Research (INSERM), Paris, Île-de-France, France., Kranzler HR; Center for Studies of Addiction, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Mann K; Central Institute for Mental Health Mannheim, Heidelberg University, Heidelberg, Delaware, USA., O'Malley SS; Department of Psychiatry, Yale School of Medicine, Yale University, New Haven, Connecticut, USA., Witkiewitz K; Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA.; Center on Alcohol, Substance use, and Addictions (CASAA), University of New Mexico, Albuquerque, New Mexico, USA.
Jazyk: angličtina
Zdroj: Alcohol, clinical & experimental research [Alcohol Clin Exp Res (Hoboken)] 2024 Feb; Vol. 48 (2), pp. 420-429. Date of Electronic Publication: 2024 Jan 11.
DOI: 10.1111/acer.15257
Abstrakt: Background: Abstinence has historically been considered the preferred goal of alcohol use disorder (AUD) treatment. However, most individuals with AUD do not want to abstain and many are able to reduce their drinking successfully. Craving is often a target of pharmacological and behavioral interventions for AUD, and reductions in craving may signal recovery. Whether reductions in drinking during AUD treatment are associated with reductions in craving has not been well examined.
Methods: We conducted secondary analyses of data from three AUD clinical trials (N's= 1327, 346, and 200). Drinking reductions from baseline to the end of treatment were measured as changes in World Health Organization (WHO) risk drinking levels; alcohol craving was measured using validated self-report measures. Regression analyses tested whether drinking reductions were associated with end-of-treatment craving reductions; moderation analyses tested whether associations between drinking reduction and end-of-treatment craving differed across AUD severity.
Results: Reductions of at least 1 or at least 2 WHO risk drinking levels were associated with lower craving (all p's < 0.05). Results were substantively similar after removing abstainers at the end-of-treatment. Associations between drinking reductions and craving were generally not moderated by AUD severity.
Conclusions: Individuals with WHO risk drinking level reductions reported significantly lower craving, as compared to those who did not achieve meaningful reductions in drinking. The results demonstrate the utility of WHO risk drinking levels as AUD clinical trial endpoints and provide evidence that drinking reductions mitigate craving.
(© 2023 Research Society on Alcohol.)
Databáze: MEDLINE
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