In vitro evaluation of the activity of Cinnamaldehyde as an inhibitor of the biological cycle of Ctenocephalides felis felis .

Autor: da Conceição CL; Veterinarian, MSc. Programa de Pós-Graduação em Ciências Veterinárias (PPGCV), Departamento de Parasitologia Animal (DPA), Instituto de Veterinária (IV), Universidade Federal Rural do Rio de Janeiro (UFRRJ). Seropédica, RJ, Brazil., Marré EO; Undergraduate in Veterinary Medicine, IV, UFRRJ. Seropédica, RJ, Brazil., da Silva YH; Veterinarian, PPGCV, DPA, IV, UFRRJ. Seropédica, RJ. Brazil., Santos LO; Undergraduate in Veterinary Medicine, IV, UFRRJ. Seropédica, RJ, Brazil., Guimarães BG; Veterinarian, MSc. Programa de Pós-Graduação em Ciências Veterinárias (PPGCV), Departamento de Parasitologia Animal (DPA), Instituto de Veterinária (IV), Universidade Federal Rural do Rio de Janeiro (UFRRJ). Seropédica, RJ, Brazil., Silva TME; Pharmacist, MSc. Programa de Pós-Graduação em Ciências Veterinárias (PPGCV), Departamento de Parasitologia Animal (DPA), IV, UFRRJ. Seropédica, RJ. Brazil., da Silva MEC; Graduate Student in Pharmacy, Departamento de Ciências Farmacêuticas, Instituto de Saúde e Ciências Biológicas, UFRRJ. Seropédica, RJ, Brazil., Campos DR; Veterinarian, DSc. PPGCV, DPA. IV, UFRRJ. Seropédica, RJ. Brazil., Scott FB; Veterinarian, DSc. DPA, IV, UFRRJ. Seropédica, RJ, Brazil., Coumendouros K; Veterinarian, DSc. DPA, IV, UFRRJ. Seropédica, RJ, Brazil.
Jazyk: angličtina
Zdroj: Brazilian journal of veterinary medicine [Braz J Vet Med] 2023 Dec 19; Vol. 45, pp. e005123. Date of Electronic Publication: 2023 Dec 19 (Print Publication: 2023).
DOI: 10.29374/2527-2179.bjvm005123
Abstrakt: The objective of this work was to evaluate the in vitro activity of cinnamaldehyde as an inhibitor of the biological cycle of Ctenocephalides felis felis . Tests were carried out with six repetitions containing 10 eggs of C. felis felis together with 0.5g of diet and filter paper discs with area of 23.76 cm 2 impregnated with different concentrations of cinnamaldehyde (6; 8; 10; 12; 14; 16; 18; 20; 24 and 28 µg.cm -2 ) in Petri dishes and incubated in a climate-controlled chamber at 27 ± 1 °C and RH 75 ± 10%, for 30 days. The tests included a placebo group containing the diluent (acetone) and a negative control group, without treatment. At the end of 30 days, the percentage of inhibition of adult emergence/mortality was calculated, as well as the LC 50 and LC 90 . Inhibition of adult emergence greater than 50% was observed from a concentration of 10 µg.cm -2 and 100% inhibition from a concentration of 14 µg.cm -2 , obtaining LC 50 and LC 90 results of 8.75 and 13.57 µg.cm -2 , respectively. We concluded that the volatile compound cinnamaldehyde is effective in vitro as an inhibitor of the biological cycle of C. felis felis .
Competing Interests: Conflict of interests: CLC, EOM, YHS, LOS, BGG, TMS, MECS, DRC, FBS, KC – No conflict of interest.
Databáze: MEDLINE
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