A rare association of a high grade glioblastoma, cerebral abscess and acute lymphoblastic leukemia in a child with Noonan syndrome.

Autor:	Boufrikha W; Department of Hematology, Fattouma Bourguiba University Hospital, Monastir, Tunisia., Rakez R; Department of Hematology, Fattouma Bourguiba University Hospital, Monastir, Tunisia., Bizid I; Department of Hematology, Fattouma Bourguiba University Hospital, Monastir, Tunisia., Hadhri MM; Department of Neurosurgery, Fattouma Bourguiba University Hospital, Monastir, Tunisia., Njima M; Department of Histopathology, Fattouma Bourguiba University Hospital, Monastir, Tunisia., Boukhris S; Department of Hematology, Fattouma Bourguiba University Hospital, Monastir, Tunisia., Laatiri MA; Department of Hematology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Jazyk:	angličtina
Zdroj:	Leukemia research reports [Leuk Res Rep] 2023 Dec 01; Vol. 21, pp. 100404. Date of Electronic Publication: 2023 Dec 01 (Print Publication: 2024).
DOI:	10.1016/j.lrr.2023.100404
Abstrakt:	Noonan syndrome is a genetic disorder frequently caused by PTPN11 mutations. Patients with Noonan syndrome are characterized by facial dysmorphism, short stature and congenital heart defects and they have a reported predisposition to malignancies such as leukemia, and solid and central nervous system tumors. Here, we report a case of a 14-year-old boy with Noonan syndrome treated for T-cell acute lymphoblastic leukemia who presented with 2 concomitant abnormalities: cerebral abscess and high grade glioblastoma. This exceptional association exhibits to a poorer prognosis and may sometimes delay the diagnosis and therefore the therapeutic intervention. Competing Interests: The authors declare no conflicts of interest in relation with this manuscript. (© 2023 The Author(s).)
Databáze:	MEDLINE
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