[The effect of rehabilitation with sensory glove and virtual reality on concentration of brain-derived neurotrophic factor and event related potential P300 in the early rehabilitation period after ischemic stroke].

Autor:	Petrova LV; Moscow Centre for Research and Clinical Practice in Medical Rehabilitation, Restorative and Sports Medicine, Moscow, Russia., Kostenko EV; Moscow Centre for Research and Clinical Practice in Medical Rehabilitation, Restorative and Sports Medicine, Moscow, Russia.; Pirogov Russian National Research Medical University, Moscow, Russia., Martynov MY; Pirogov Russian National Research Medical University, Moscow, Russia.; Federal Center for Brain and Neurotechnologies, Moscow, Russia., Pogonchenkova IV; Moscow Centre for Research and Clinical Practice in Medical Rehabilitation, Restorative and Sports Medicine, Moscow, Russia., Kopasheva VD; Moscow Centre for Research and Clinical Practice in Medical Rehabilitation, Restorative and Sports Medicine, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2023; Vol. 123 (12. Vyp. 2), pp. 75-81.
DOI:	10.17116/jnevro202312312275
Abstrakt:	Objective: To study the effect of rehabilitation with sensory glove (SG) and virtual reality (VR) on changes in brain-derived neurotrophic factor (BDNF) concentration and amplitude and latency of event related potential (ERP) P300 in the early rehabilitation period after hemispheric ischemic stroke (IS). Material and Methods: Ninety patients (mean age 58.0±9.7 years, time after stroke onset - 3.8±1.6 months) were randomized into intervention (IG) and control (CG) groups. Patients in both groups received 15 sessions of rehabilitation (30 min, 3 times a week). Patients in the IG ( n =46) received rehabilitation with SG and VR. Patients in CG ( n =44) received individualized physical therapy. The end points were a change in the MMSE, MoCA, 10-word Luria test, subtests of Wechsler Adult Intelligence Scale IV (WAIS IV) test, amplitude and latency of P300, and BDNF concentration on admission and at the end of rehabilitation. Results: There was an improvement on MoCA test ( p =0.049) and working memory index of the WAIS IV test ( p =0.045) iIn the IG after completing rehabilitation the improvement on MoCA test ( p =0.049) and working memory index of the WAIS IV test ( p =0.045) was observed. There was aA trend tendency towards an significant increase on MMSE ( p =0.093) and 10-word Luria test ( p =0.052) was observed. In CG, an improvement with a trend towards significant differences ( p ≤0.12) on all above mentioned tests was also observednoted. In both groups there were no significant changes in the amplitude or latency of P300. Concentration of BDNF increased significantly in the IG ( p =0.042), while in the CG a tendency ( p =0.064) was observed ( p =0.064). By the end of rehabilitation, the delta between groups in the increase of BDNF concentration was 17.9%, p =0.072. In both groups, there was a correlation between scores on cognitive tests and BDNF concentration. Absence/presence of cognitive disorders was not associated with initial or final BDNF concentrations or delta between groups. Results: In the IG after completing rehabilitation the improvement on MoCA test ( p =0.049) and working memory index of the WAIS IV test ( p =0.045) was observed. There was a tendency towards significant increase on MMSE ( p =0.093) and 10 word Luria test ( p =0.052). In CG an improvement with a trend towards significant differences ( p ≤0.12) on all above mentioned tests was also observed. In both groups there were no significant changes in the amplitude or latency of P300. Concentration of BDNF increased significantly in the IG ( p =0.042), while in the CG a tendency was observed ( p =0.064). By the end of rehabilitation, the delta between groups in the increase of BDNF concentration was 17.9%, p =0.072. In both groups there was a correlation between scores on cognitive tests and BDNF concentration. Absence/presence of cognitive disorders was not associated with initial or final BDNF concentration or delta between groups. Conclusion: VR and SG in the early rehabilitation period after IS is are as equally effective as rehabilitation with individualized physical therapy (aerobic training) in increasing BDNF concentration and in improvement on cognitive tests.
Databáze:	MEDLINE
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