The Persistence of Hypertriglyceridemia and the Risk of Early Onset Colorectal Cancer According to Tumor Subsites: A Nationwide Population-Based Study.

Autor: Chang YH; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Shin CM; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Han K; Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea., Jung JH; Department of Medical Statistics, College of Medicine, The Catholic University of Korea, Seoul, Korea., Jin EH; Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea., Lim JH; Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea., Kang SJ; Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea., Choi YJ; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.; Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea., Yoon H; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Park YS; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Kim N; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea., Lee DH; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Jazyk: angličtina
Zdroj: Cancer research and treatment [Cancer Res Treat] 2024 Jul; Vol. 56 (3), pp. 825-837. Date of Electronic Publication: 2023 Dec 20.
DOI: 10.4143/crt.2023.753
Abstrakt: Purpose: The incidence of early-onset colorectal cancer (EoCRC) is increasing worldwide. The association between hypertriglyceridemia (HTG) and EoCRC risk remains unclear.
Materials and Methods: We conducted a nationwide cohort study of 3,340,635 individuals aged 20-49 years who underwent health checkups between 2009 and 2011 under the Korean National Health Insurance Service. HTG was defined as serum triglyceride (TG) level ≥ 150 mg/dL. According to the change in TG status, participants were categorized into persistent normotriglyceridemia (NTG; group 1), NTG to HTG (group 2), HTG to NTG (group 3), and persistent HTG (group 4) groups. The EoCRC incidence was followed up until 2019.
Results: In total, 7,492 EoCRC cases developed after a mean of 6.05 years of follow-up. Group 4 had the highest risk of EoCRC (adjusted hazard ratio [aHR], 1.097; 95% confidence interval [CI], 1.025 to 1.174). While the risk of rectal cancer was significantly increased in groups 3 and 4 (aHR [95% CI], 1.236 [1.076 to 1.419] and 1.175 [1.042-1.325], respectively), no significant risk differences were observed in right colon cancer. In group 4, male sex and diabetes were associated with a further increased risk of EoCRC (aHR [95% CI], 1.149 [1.082 to 1.221] and 1.409 [1.169 to 1.699], respectively). In addition, there was a dose-response relationship between serum TG levels and the risk of EoCRC (p for trends < 0.0001).
Conclusion: Persistent HTG increased the risk of EoCRC, which was significantly higher only for rectal cancer and marginally higher for other colonic subsites.
Databáze: MEDLINE
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