Social anxiety disorder-associated gut microbiota increases social fear.

Autor:	Ritz NL; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland., Brocka M; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland., Butler MI; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland.; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork T12YT20, Ireland., Cowan CSM; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland., Barrera-Bugueño C; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland., Turkington CJR; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland.; School of Microbiology, University College Cork, Cork T12K8AF, Ireland., Draper LA; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland.; School of Microbiology, University College Cork, Cork T12K8AF, Ireland., Bastiaanssen TFS; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland., Turpin V; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland., Morales L; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland., Campos D; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland., Gheorghe CE; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland.; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork T12YT20, Ireland., Ratsika A; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland., Sharma V; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland.; School of Microbiology, University College Cork, Cork T12K8AF, Ireland., Golubeva AV; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland., Aburto MR; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland., Shkoporov AN; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland.; School of Microbiology, University College Cork, Cork T12K8AF, Ireland., Moloney GM; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland., Hill C; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland.; School of Microbiology, University College Cork, Cork T12K8AF, Ireland., Clarke G; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland.; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork T12YT20, Ireland., Slattery DA; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Frankfurt 60528, Germany., Dinan TG; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland.; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork T12YT20, Ireland., Cryan JF; Alimentary Pharmabiotic Centre Microbiome Ireland, University College Cork, Cork T12YT20, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork T12YT20, Ireland.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jan 02; Vol. 121 (1), pp. e2308706120. Date of Electronic Publication: 2023 Dec 26.
DOI:	10.1073/pnas.2308706120
Abstrakt:	Social anxiety disorder (SAD) is a crippling psychiatric disorder characterized by intense fear or anxiety in social situations and their avoidance. However, the underlying biology of SAD is unclear and better treatments are needed. Recently, the gut microbiota has emerged as a key regulator of both brain and behaviour, especially those related to social function. Moreover, increasing data supports a role for immune function and oxytocin signalling in social responses. To investigate whether the gut microbiota plays a causal role in modulating behaviours relevant to SAD, we transplanted the microbiota from SAD patients, which was identified by 16S rRNA sequencing to be of a differential composition compared to healthy controls, to mice. Although the mice that received the SAD microbiota had normal behaviours across a battery of tests designed to assess depression and general anxiety-like behaviours, they had a specific heightened sensitivity to social fear, a model of SAD. This distinct heightened social fear response was coupled with changes in central and peripheral immune function and oxytocin expression in the bed nucleus of the stria terminalis. This work demonstrates an interkingdom basis for social fear responses and posits the microbiome as a potential therapeutic target for SAD. Competing Interests: Competing interests statement:The authors declare no competing interest.
Databáze:	MEDLINE
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