Functionalization of selenium nanoparticles with olive polyphenols - impact on toxicity and antioxidative activity.

Autor:	Galić E; 1Faculty of Agrobiotechnical Sciences Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek Croatia.; 2University of Zagreb Faculty of Pharmacy and Biochemistry, 10000 Zagreb, Croatia., Radić K; 2University of Zagreb Faculty of Pharmacy and Biochemistry, 10000 Zagreb, Croatia., Golub N; 2University of Zagreb Faculty of Pharmacy and Biochemistry, 10000 Zagreb, Croatia., Mlinar J; 2University of Zagreb Faculty of Pharmacy and Biochemistry, 10000 Zagreb, Croatia., Čepo DV; 2University of Zagreb Faculty of Pharmacy and Biochemistry, 10000 Zagreb, Croatia., Vinković T; 1Faculty of Agrobiotechnical Sciences Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek Croatia.
Jazyk:	angličtina
Zdroj:	Acta pharmaceutica (Zagreb, Croatia) [Acta Pharm] 2023 Dec 26; Vol. 73 (4), pp. 617-631. Date of Electronic Publication: 2023 Dec 26 (Print Publication: 2023).
DOI:	10.2478/acph-2023-0036
Abstrakt:	Selenium nanoparticles (SeNPs) represent novel selenium (Se) formulation characterized by improved biocompatibility and a wider therapeutic range in comparison to inorganic Se. The aim of this work was to investigate the possibilities of functionalization of SeNPs with olive pomace extract (OPE), rich in health-promoting polyphenols, and to obtain innovative forms of nutraceuticals. Cytotoxic and antioxidative activities of four types of SeNPs (polyvinylpyrrolidone stabilized (PVP SeNPs), polysorbate stabilized (PS SeNPs), polyvinylpyrrolidone stabilized and functionalized using OPE (f PVP SeNPs) and polysorbate stabilized and functionalized using OPE (f PS SeNPs) were investigated. SeNPs showed lower toxicity on human hepatocellular carcinoma (HepG2) and human colorectal adenocarcinoma (Caco2) cells compared to selenite. Functionalization with polyphenols significantly improved their direct antiradical (f PVP SeNPs: 24.4 ± 1.84 and f PS SeNPs: 30.9 ± 2.47 mg TE/mmol Se) and reducing properties (f PVP SeNPs: 50 ± 3.16 and f PS SeNPs: 53.6 ± 3.22 mg GAE/mmol) compared to non-functionalized SeNPs. The significant impact of tested SeNPs on intracellular antioxidative mechanisms has been observed and it was dependent on both cell type and physico-chemical properties of SeNPs, indicating the complexity of involved mechanisms. (© 2023 Emerik Galić et al., published by Sciendo.)
Databáze:	MEDLINE
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