Relationship between exposure to parabens and benzophenones and prostate cancer risk in the EPIC-Spain cohort.

Autor: Fernández-Martínez NF; Instituto de Investigación Biosanitaria Ibs.GRANADA, 18012, Granada, Spain.; Escuela Andaluza de Salud Pública (EASP), Cuesta del Observatorio, 4. 18011, Granada, Spain.; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain., Rodríguez-Barranco M; Instituto de Investigación Biosanitaria Ibs.GRANADA, 18012, Granada, Spain. miguel.rodriguez.barranco.easp@juntadeandalucia.es.; Escuela Andaluza de Salud Pública (EASP), Cuesta del Observatorio, 4. 18011, Granada, Spain. miguel.rodriguez.barranco.easp@juntadeandalucia.es.; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain. miguel.rodriguez.barranco.easp@juntadeandalucia.es., Zamora-Ros R; Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908, Barcelona, Spain., Guevara M; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain.; Navarra Public Health Institute, 31003, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), 31008, Pamplona, Spain., Colorado-Yohar SM; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain.; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, 30008, Murcia, Spain., Jiménez-Zabala A; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain.; Sub Directorate for Public Health and Addictions of Gipuzkoa, Ministry of Health of the Basque Government, 20013, San Sebastian, Spain.; Biodonostia Health Research Institute, 20014, San Sebastián, Spain., Arrebola JP; Instituto de Investigación Biosanitaria Ibs.GRANADA, 18012, Granada, Spain.; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain.; Department of Preventive Medicine and Public Health, University of Granada, 18071, Granada, Spain., Iribarne-Durán LM; Instituto de Investigación Biosanitaria Ibs.GRANADA, 18012, Granada, Spain.; Department of Radiology, School of Medicine, University of Granada, 18071, Granada, Spain., Molina G; Department of Preventive Medicine and Public Health, University Hospital of Santiago de Compostela, 15706 A, Coruña, Spain., Agudo A; Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908, Barcelona, Spain., Trobajo-Sanmartín C; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain.; Navarra Public Health Institute, 31003, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), 31008, Pamplona, Spain., Chirlaque MD; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain.; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, 30008, Murcia, Spain.; Department of Health and Social Sciences, Murcia University, 30100, Murcia, Spain., Amiano P; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain.; Sub Directorate for Public Health and Addictions of Gipuzkoa, Ministry of Health of the Basque Government, 20013, San Sebastian, Spain.; Biodonostia Health Research Institute, 20014, San Sebastián, Spain., Sánchez MJ; Instituto de Investigación Biosanitaria Ibs.GRANADA, 18012, Granada, Spain.; Escuela Andaluza de Salud Pública (EASP), Cuesta del Observatorio, 4. 18011, Granada, Spain.; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain.; Department of Preventive Medicine and Public Health, University of Granada, 18071, Granada, Spain.
Jazyk: angličtina
Zdroj: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2024 Jan; Vol. 31 (4), pp. 6186-6199. Date of Electronic Publication: 2023 Dec 26.
DOI: 10.1007/s11356-023-31682-3
Abstrakt: The etiology of prostate cancer is not fully elucidated. Among environmental risk factors, endocrine-disrupting chemicals (EDCs) deserve special mention, as they alter metabolic pathways involved in hormone-dependent cancers. Epidemiological evidence assessing the carcinogenicity of EDCs is scarce. The aim of this study was to analyze the relationship between exposure to parabens and benzophenones and prostate cancer risk. We conducted a case-cohort study nested within the EPIC-Spain prospective multi-center cohort. Study population comprised 1,838 sub-cohort participants and 467 non-sub-cohort prostate cancer cases. Serum concentrations of four parabens and two benzophenones were assessed at recruitment. Covariates included age, physical activity, tobacco smoking, alcohol consumption, body mass index, educational level and diabetes. Borgan II weighted Cox proportional hazard models stratified by study center were applied. Median follow-up time was 18.6 years (range = 1.0-21.7 years). Most sub-cohort participants reached primary education at most (65.5%), were overweight (57.7%) and had a low level of physical activity (51.3%). Detection percentages varied widely, being lowest for butyl-paraben (11.3%) and highest for methyl-paraben (80.7%), which also showed the highest geometric mean (0.95 ng/ml). Cases showed significantly higher concentrations of methyl-paraben (p = 0.041) and propyl-paraben (p < 0.001). In the multivariable analysis, methyl-paraben - log-transformed (HR = 1.07; 95%CI = 1.01-1.12) and categorized into tertiles (HR = 1.60 for T3; 95%CI = 1.16-2.20) -, butyl-paraben - linear (HR = 1.19; 95%CI = 1.14-1.23) and log-transformed (HR = 1.17; 95%CI = 1.01-1.35) - and total parabens - log-transformed (HR = 1.09; 95%CI = 1.02-1.17) and categorized into tertiles (HR = 1.62 for T3; 95%CI = 1.10-2.40) - were associated with an increased prostate cancer risk. In this study, higher concentrations of methyl-, butyl-, and total parabens were positively associated with prostate cancer risk. Further research is warranted to confirm these findings.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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