The evolutionary dynamics of local adaptations under genetic rescue is determined by mutational load and polygenicity.

Autor:	Zhang Y; School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China.; Center for Computational Biology, UC Berkeley, Berkeley, CA, United States., Stern AJ; Center for Computational Biology, UC Berkeley, Berkeley, CA, United States., Nielsen R; Department of Integrative Biology, UC Berkeley, Berkeley, CA, United States.; Department of Statistics, UC Berkeley, Berkeley, CA, United States.; Center for GeoGenetics, Globe Institute, University of Copenhagen, Copenhagen, Denmark.
Jazyk:	angličtina
Zdroj:	The Journal of heredity [J Hered] 2024 Jul 10; Vol. 115 (4), pp. 373-384.
DOI:	10.1093/jhered/esad079
Abstrakt:	Inbred populations often suffer from increased mutational load and reduced fitness due to lower efficacy of purifying selection in groups with small effective population sizes. Genetic rescue (GR) is a conservation tool that is studied and deployed with the aim of increasing the fitness of such inbred populations by assisted migration of individuals from closely related outbred populations. The success of GR depends on several factors-such as their demographic history and distribution of dominance effects of mutations-that may vary across populations. While we understand the impact of these factors on the dynamics of GR, their impact on local adaptations remains unclear. To this end, we conduct a population genetics simulation study to evaluate the impact of trait complexity (Mendelian vs. polygenic), dominance effects, and demographic history on the efficacy of GR. We find that the impact on local adaptations depends highly on the mutational load at the time of GR, which is in turn shaped dynamically by interactions between demographic history and dominance effects of deleterious variation. Over time local adaptations are generally restored post-GR, though in the short term they are often compromised in the process of purging deleterious variation. We also show that while local adaptations are almost always fully restored, the degree to which ancestral genetic variation affecting the trait is replaced by donor variation can vary drastically and is especially high for complex traits. Our results provide insights on the impact of GR on trait evolution and considerations for the practical implementation of GR. (© The Author(s) 2023. Published by Oxford University Press on behalf of The American Genetic Association. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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