Antimalarial activities of benzothiazole analogs: A systematic review.

Autor: Tran L; Institute of Fundamental and Applied Sciences, Duy Tan University, Ho Chi Minh City, Vietnam.; Faculty of Natural Sciences, Duy Tan University, Da Nang, Vietnam., Tu VL; Online Research Club (https://www.onlineresearchclub.org/), Nagasaki, Japan.; Faculty of Traditional Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Dadam MN; Online Research Club (https://www.onlineresearchclub.org/), Nagasaki, Japan.; Department of Geriatrics, Helios Klinikum Schwelm, Schwelm, Germany., Aziz JMA; Biomedical Science Department, Komar University of Science and Technology, Sulaimaniyah, Kurdistan Region, Iraq.; Baxshin Research Center, Baxshin Hospital, Sulaimaniyah, Kurdistan Region, Iraq., Duy TLD; Online Research Club (https://www.onlineresearchclub.org/), Nagasaki, Japan.; College of Health Sciences, VinUniversity, Hanoi, Vietnam., Ahmed HHH; Online Research Club (https://www.onlineresearchclub.org/), Nagasaki, Japan.; Faculty of Medicine, Alzaiem Alazhari University, Khartoum, Sudan., Kwaah PA; Online Research Club (https://www.onlineresearchclub.org/), Nagasaki, Japan.; Department of Internal Medicine, Yale School of Medicine, Yale-Waterbury Internal Medicine Program, Waterbury, Connecticut, USA., Quoc HN; Online Research Club (https://www.onlineresearchclub.org/), Nagasaki, Japan.; Vietnam Military Medical University, Hanoi, Vietnam., Van Dat T; Ministry of Health Cabinet, Ministry of Health, Ha Noi, Vietnam., Mizuta S; Center for Bioinformatics and Molecular Medicine, Nagasaki University, Nagasaki, Japan., Hirayama K; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan., Huy NT; Institute of Fundamental and Applied Sciences, Duy Tan University, Ho Chi Minh City, Vietnam.; Faculty of Natural Sciences, Duy Tan University, Da Nang, Vietnam.; Online Research Club (https://www.onlineresearchclub.org/), Nagasaki, Japan.; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.
Jazyk: angličtina
Zdroj: Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2024 Jun; Vol. 38 (3), pp. 410-464. Date of Electronic Publication: 2023 Dec 26.
DOI: 10.1111/fcp.12974
Abstrakt: Background: Benzothiazole derivatives have been reported to possess a wide range of biological activities, including antimalarial activity. This systematic review aims to summarize and evaluate the antimalarial activities of benzothiazole analogs.
Methods: We conducted an electronic search using nine databases in October 2017 and subsequently updated in September 2022. We included all original in vitro and in vivo studies that documented the antimalarial activities of compounds containing benzothiazole analogs with no restriction. The risk of bias of each included study was assessed by ToxRTool.
Results: Twenty-eight articles were included in our study, which are in vitro, in vivo, or both. Of these, 232 substances were identified to have potent antiplasmodial activity against various strains of the malaria parasite. Benzothiazole analogs show different antimalarial mechanisms, including inhibition of Plasmodium falciparum enzymes in in vitro studies and inhibition of blood parasites in in vivo studies.
Conclusions: Benzothiazole derivatives are promising substances for treating malaria. The structure-activity relationship studies suggest that the substitution pattern of the benzothiazole scaffold plays a crucial role in determining the antimalarial activity of the analog.
(© 2023 Société Française de Pharmacologie et de Thérapeutique. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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