Degenerative Thoracic Myelopathy: A Scoping Review of Epidemiology, Genetics, and Pathogenesis.

Autor:	Rujeedawa T; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Mowforth OD; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Davies BM; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Yang C; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Nouri A; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland., Francis JJ; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Aarabi B; University of Maryland, Baltimore, MD, USA., Kwon BK; Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada., Harrop J; Thomas Jefferson University Hospital, Philadelphia, PA, USA., Wilson JR; University of Toronto, Toronto, ON, Canada., Martin AR; Department of Neurosurgery, University of California Davis, Sacramento, CA, USA., Rahimi-Movaghar V; Department of Neurosurgery, Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran., Guest JD; Department of Neurosurgery and The Miami Project to Cure Paralysis, The Miller School of Medicine, University of Miami, Miami, FL, USA., Fehlings MG; Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada., Kotter MR; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Jazyk:	angličtina
Zdroj:	Global spine journal [Global Spine J] 2024 Jun; Vol. 14 (5), pp. 1664-1677. Date of Electronic Publication: 2023 Dec 26.
DOI:	10.1177/21925682231224768
Abstrakt:	Study Design: Literature Review. Objective: Myelopathy affecting the thoracic spinal cord can arise secondary to several aetiologies which have similar presentation and management. Consequently, there are many uncertainties in this area, including optimal terminology and definitions. Recent collaborative cervical spinal research has led to the proposal and subsequent community adoption of the name degenerative cervical myelopathy(DCM) , which has facilitated the establishment of internationally-agreed research priorities for DCM. We put forward the case for the introduction of the term degenerative thoracic myelopathy(DTM) and degenerative spinal myelopathy(DSM) as an umbrella term for both DCM and DTM . Methods: Following PRISMA guidelines, a systematic literature search was performed to identify degenerative thoracic myelopathy literature in Embase and MEDLINE. Results: Conditions encompassed within DTM include thoracic spondylotic myelopathy, ossification of the posterior longitudinal ligament, ossification of the ligamentum flavum, calcification of ligaments, hypertrophy of ligaments, degenerative disc disease, thoracic osteoarthritis, intervertebral disc herniation, and posterior osteophytosis. The classic presentation includes girdle pain, gait disturbance, leg weakness, sensory disturbance, and bladder or bowel dysfunction, often with associated back pain. Surgical management is typically favoured with post-surgical outcomes dependent on many factors, including the causative pathology, and presence of additional stenosis. Conclusion: The clinical entities encompassed by the term DTM are interrelated, can manifest concurrently, and present similarly. Building on the consensus adoption of DCM in the cervical spine and the recent proposal of degenerative cervical radiculopathy(DCR) , extending this common nomenclature framework to the terms degenerative spinal myelopathy and degenerative thoracic myelopathy will help improve recognition and communication. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu