Treatment adherence in retinoblastoma: A retro-prospective cohort study in Ivory Coast and the Democratic Republic of Congo.

Autor: Lukamba RM; Department of Pediatrics (Pediatric Oncology Unit), University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo (DRC)., Budiongo AN; Department of Pediatrics (Pediatric Oncology Unit), University of Kinshasa, Kinshasa, Democratic Republic of the Congo (DRC)., Monga BB; Faculty of Medicine and School of Public Health, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo (DRC)., Yao A; Pediatric Oncology Unit, University Teaching Hospital of Treichville, Abidjan, Ivory Coast., Bey P; Advisor to the President of Institut Curie, University of Lorraine and AMCC, Paris, France., Chenge GB; Ophthalmology Department, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo (DRC)., Desjardins L; Ophthalmology Service, Institut Curie and AMCC, Paris, France., Doz F; SIREDO Oncology Center (Care, Innovation, Research in Child Oncology, Adolescent and Young Adult) Institut Curie and University Paris Cité, Paris, France., Mwembo AT; Faculty of Medicine and School of Public Health, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo (DRC)., Kabesha TA; Bukavu Ophthalmic Clinic, Bukavu Official University, Bukavu, Democratic Republic of the Congo (DRC)., Luboya ON; Department of Pediatrics and School of Public Health, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo (DRC).
Jazyk: angličtina
Zdroj: Cancer reports (Hoboken, N.J.) [Cancer Rep (Hoboken)] 2023 Dec 26, pp. e1949. Date of Electronic Publication: 2023 Dec 26.
DOI: 10.1002/cnr2.1949
Abstrakt: Background: In high-income countries, retinoblastoma is curable in more than 95% of cases, whereas in low-income countries, mortality remains high, especially when the diagnosis is made late or the treatment is discontinued.
Aims: To determine the factors associated with adherence to the treatment of retinoblastoma in the Ivory Coast and the Democratic Republic of Congo (DRC).
Methods and Results: A retro-prospective cohort study was carried out. Data were collected from patient folders and follow-up records of parents.
Results: A total of 175 children with retinoblastoma were registered from January 2013 to December 2015. Seventy-six children (43%) were 5 years old and above. Care costs were covered by families in 86.9% of cases. Chemotherapy refusal was recorded in 39 cases (22.3%), and enucleation refusal was recorded in 79 cases (45.1%). After 36 months of follow-up, we recorded 16.6% deaths, 27.4% treatment dropouts, and 18.3% loss to follow-up after treatment. The commonest cause for enucleation refusal was fear of infirmity, while chemotherapy refusal and absconding treatment were due to financial constraints.
Conclusion: Poor adherence to retinoblastoma management was due to financial constraints, and a lack of knowledge of the disease and its treatment. Family psychosocial support is needed to improve this condition.
(© 2023 The Authors. Cancer Reports published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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