Declining frequency of sensitization to fragrance mixes I and II: IVDK-data of the years 2012-2021.

Autor: Geier J; Information Network of Departments of Dermatology (IVDK), Institute at the University Medical Center Göttingen, Göttingen, Germany., Schubert S; Information Network of Departments of Dermatology (IVDK), Institute at the University Medical Center Göttingen, Göttingen, Germany., Rieker-Schwienbacher J; Center for Dermatology, Phlebology and Allergology, Klinikum Stuttgart, Stuttgart, Germany., Brans R; Institute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm) at the Osnabrück University, Osnabrück, Germany.; Department of Dermatology, Environmental Medicine and Health Theory, Osnabrück University, Osnabrück, Germany., Weisshaar E; Unit for Occupational Dermatology, Department of Dermatology, Ruprecht-Karls University Heidelberg, Heidelberg, Germany., Kränke B; Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria., Brockow K; Department of Dermatology and Allergology, Technical University Munich, Munich, Germany., Ruёff F; Department of Dermatology and Allergy, LMU University Hospital, LMU Munich, Munich, Germany., Recke A; Department of Dermatology, Allergology and Venereology, University of Luebeck, Luebeck, Germany., Uter W; Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen/Nürnberg, Erlangen, Germany.
Jazyk: angličtina
Zdroj: Contact dermatitis [Contact Dermatitis] 2024 May; Vol. 90 (5), pp. 470-478. Date of Electronic Publication: 2023 Dec 25.
DOI: 10.1111/cod.14493
Abstrakt: Background: EU Commission Regulation 2017/1410 prohibits using atranol and chloroatranol, the main allergens in Evernia prunastri (oakmoss), and hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) in cosmetic products. Oakmoss absolute is contained in fragrance mix (FM) I and HICC in FM II which are patch tested as screening mixtures in the baseline series.
Objective: To describe the time trends of reaction frequencies to both FMs as well as to their components in FM-positive patients.
Methods: Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK), 2012-2021.
Results: Positive reactions to FM I (FM II) declined from 9.1% (4.7%) in 2012 to 4.6% (3.0%) in 2021. Full breakdown tests were performed in 24% (FM I) and 31% (FM II), respectively, of the mix-positive patients. From this data, frequencies of sensitization to the 14 single fragrances of FM I and FM II were calculated. For the majority, a decline was noted from 2012/2013 to 2020/2021, for oakmoss absolute 1.9%-0.8% and for HICC 1.8%-0.9%.
Conclusion: EU Commission Regulation 2017/1410 was an effective measure. However, our data have some limitations, possibly causing underestimation of sensitization frequencies to fragrances.
(© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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