Non-apoptotic cell death programs in cervical cancer with an emphasis on ferroptosis.

Autor: Samare-Najaf M; Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Kerman Regional Blood Transfusion Center, Kerman, Iran. Electronic address: samaremohamad@gmail.com., Samareh A; Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: samarehali@yahoo.com., Savardashtaki A; Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran; Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: dashtaki@sums.ac.ir., Khajehyar N; Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Kerman Regional Blood Transfusion Center, Kerman, Iran., Tajbakhsh A; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran., Vakili S; Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: sinavakili68@gmail.com., Moghadam D; Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran., Rastegar S; Department of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran., Mohsenizadeh M; Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Kerman Regional Blood Transfusion Center, Kerman, Iran., Jahromi BN; Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Vafadar A; Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran., Zarei R; Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Jazyk: angličtina
Zdroj: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2024 Feb; Vol. 194, pp. 104249. Date of Electronic Publication: 2023 Dec 23.
DOI: 10.1016/j.critrevonc.2023.104249
Abstrakt: Background: Cervical cancer, a pernicious gynecological malignancy, causes the mortality of hundreds of thousands of females worldwide. Despite a considerable decline in mortality, the surging incidence rate among younger women has raised serious concerns. Immortality is the most important characteristic of tumor cells, hence the carcinogenesis of cervical cancer cells pivotally requires compromising with cell death mechanisms.
Methods: The current study comprehensively reviewed the mechanisms of non-apoptotic cell death programs to provide possible disease management strategies.
Results: Comprehensive evidence has stated that focusing on necroptosis, pyroptosis, and autophagy for disease management is associated with significant limitations such as insufficient understanding, contradictory functions, dependence on disease stage, and complexity of intracellular pathways. However, ferroptosis represents a predictable role in cervix carcinogenesis, and ferroptosis-related genes demonstrate a remarkable correlation with patient survival and clinical outcomes.
Conclusion: Ferroptosis may be an appropriate option for disease management strategies from predicting prognosis to treatment.
Competing Interests: Declaration of Competing Interest No potential conflict of interest was reported by the author(s).
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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