Clinical and Electrophysiological Characterization of Essential Tremor in 18 Children and Adolescents.

Autor:	Piarroux J; Department of Pediatric Neurology, Gui de Chauliac University Hospital, Montpellier, France., Dimopoulou E; Department of Pediatric Neurology, Gui de Chauliac University Hospital, Montpellier, France., Taieb G; University of Montpellier, CNRS (IGF), Department of Neurology, Montpellier, University Hospital 34295 Montpellier, France., Souvannanorath S; Reference center for neuromuscular diseases, Henri-Mondor University Hospital, Assistance publique-Hôpitaux de Paris, Créteil, France., Roze E; Department of Neurology, Salpêtrière Hospital, Sorbonne University and Assistance Publique - Hôpitaux de Paris, Paris, France., Lion-François L; Department of Pediatric Neurology, Lyon University Hospital, Bron, France., Spitz MA; Department of Pediatry, Strasbourg University Hospitals, Strasbourg, France., Broussolle E; Research Unit UMR 5229, Marc-Jeannerod Institute of Cognitive Science, French National Center for Scientific Research (CNRS), University of Lyon, Bron, France.; Department of Neurology C, Civil Hospices of Lyon, Pierre-Wertheimer Neurological Hospital, Bron, France.; Faculty of Medicine Lyon-Sud Charles-Mérieux, University of Lyon, Oullins, France., Laurencin C; Department of Neurology C, Civil Hospices of Lyon, Pierre-Wertheimer Neurological Hospital, Bron, France.; Lyon Neuroscience Research Center (CRNL), INSERM U1028, CNRS UMR5292, University Lyon 1, Lyon F-69000, France., Chanson JB; Department of Neurology, Strasbourg University Hospitals, Strasbourg, France and Reference centre for neuromuscular diseases Nord/Est/Ile-de-France, France., Belleville-Goffeney J; Departement of Pediatric Neurology, Jean-Minjoz University Hospital, Besançon, France., François-Heude MC; Department of Pediatric Neurology, Gui de Chauliac University Hospital, Montpellier, France., Meyer P; Department of Pediatric Neurology, Gui de Chauliac University Hospital, Montpellier, France., Khalil M; Clinical Investigation Center, Montpellier University Hospital, France. INSERM, CIC1411, Montpellier, France., Dereure M; Clinical Research and Epidemiology Unit, La Colombière University Hospital, Montpellier, France., Doummar D; Department of Pediatric Neurology and developmental pathologies, Sorbonne University and Trousseau University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France, APHP. SU, FHU I2D2, F-75012, Paris, France., Chevassus H; Clinical Investigation Center, Montpellier University Hospital, France. INSERM, CIC1411, Montpellier, France., Apartis E; Department of Neurophysiology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris, INSERM U1127, CNRS UMR7225, UM75, ICM, 75013 Paris, France., Roubertie A; Department of Pediatric Neurology, Gui de Chauliac University Hospital, Montpellier, France.; Institute for Neurosciences of Montpellier, INSERM U 1298, University of Montpellier, Montpellier, France.
Jazyk:	angličtina
Zdroj:	Tremor and other hyperkinetic movements (New York, N.Y.) [Tremor Other Hyperkinet Mov (N Y)] 2023 Dec 20; Vol. 13, pp. 46. Date of Electronic Publication: 2023 Dec 20 (Print Publication: 2023).
DOI:	10.5334/tohm.803
Abstrakt:	Background: Essential tremor (ET) is considered the most frequent abnormal movement in the general population, with childhood onset in 5 to 30% of the patients. Methods: A multicenter, descriptive cross-sectional study enrolled patients ⩽18 years with a definite diagnosis of ET according to the International Parkinson and Movement Disorders Society criteria. Demographic data, clinical and electrophysiological characteristics of the tremor, neurological examination and impact on quality of life were collected. Results: 9 males and 9 females were included (mean age of 13.9 years). Tremor was characterized by : upper limb onset at a mean age of 6.5 years; at enrollment, upper limbs localization, and involvement of an additional body region in 28% of the patients; kinetic tremor in all of the patients combined with postural tremor in 17 and rest tremor in 3; tremor mean frequency of 7.6 Hz, mean burst duration of 82.7 ms; identification of mild myoclonic jerks on the polymyographic recordings in 7 patients; altered quality of life with worse emotional outcomes in girls and when a disease duration >5 years was suggested. Discussion: Childhood-onset ET is associated with delayed diagnosis and remarkable functional impact. Electromyographic identification of additional mild myoclonus is a new finding whose significance is discussed. Highlights: ET onset involved upper limbs and at inclusion, 28% of the patients exhibited involvement of an additional body region.ET impacted quality of life for all patients.Girls and patients affected for >5 years reported worse emotional outcomes.Mild myoclonic jerks were identified on 7/17 polymyographic recordings. Competing Interests: The authors have no competing interests to declare. (Copyright: © 2023 The Author(s).)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu