Big peptide drugs in a small molecule world.
| Autor: | Otvos L Jr; Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary.; OLPE Pharmaceutical Consultants, Audubon, PA, United States., Wade JD; Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.; School of Chemistry, University of Melbourne, Parkville, VIC, Australia. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in chemistry [Front Chem] 2023 Dec 07; Vol. 11, pp. 1302169. Date of Electronic Publication: 2023 Dec 07 (Print Publication: 2023). |
| DOI: | 10.3389/fchem.2023.1302169 |
| Abstrakt: | A quarter of a century ago, designer peptide drugs finally broke through the glass ceiling. Despite the resistance by big pharma, biotechnology companies managed to develop injectable peptide-based drugs, first against orphan or other small volume diseases, and later for conditions affecting large patient populations such as type 2 diabetes. Even their lack of gastrointestinal absorption could be utilized to enable successful oral dosing against chronic constipation. The preference of peptide therapeutics over small molecule competitors against identical medical conditions can be achieved by careful target selection, intrachain and terminal amino acid modifications, appropriate conjugation to stability enhancers and chemical space expansion, innovative delivery and administration techniques and patient-focused marketing strategies. Unfortunately, however, pharmacoeconomical considerations, including the strength of big pharma to develop competing small molecule drugs, have somewhat limited the success of otherwise smart peptide-based therapeutics. Yet, with increasing improvement in peptide drug modification and formulation, these are continuing to gain significant, and growing, acceptance as desirable alternatives to small molecule compounds. Competing Interests: Author LO was employed by OLPE Pharmaceutical Consultants. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declared that they were editorial board members of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2023 Otvos and Wade.) |
| Databáze: | MEDLINE |
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